During the first three quarters of the twentieth century, radical mastectomy was an accepted and common procedure in the management of patients with early stage cancer of the breast. After a lifetime of thinking about and working with patients with early-stage breast cancer, Vera Peters presented and published, in the mid-1970s, a retrospective historical case-control study that demonstrated th...

BACKGROUND In their article on "Evidence-based de-implementation for contradicted, unproven, and aspiring healthcare practices," Prasad and Ioannidis (IS 9:1, 2014) referred to extra-scientific "entrenched practices and other biases" that hinder evidence-based de-implementation. DISCUSSION Using the case example of the de-implementation of radical mastectomy, we disaggregated "entrenched prac...

The outcome in 57 male patients with breast cancer has been analysed. Four patients with early disease had simple mastectomy (one case) and radical mastectomy (three cases). All four completed a 12-cycle cyclophosphamide/methotrexate/5-fluorouracil (CMF) course of chemotherapy. Two required orchiectomy after 23 and 38 months, respectively. Two patients were alive at 79 and 63 months. Fifty-thre...

Breast reconstruction (BR) surgery is not common for the treatment of breast cancer in low- and middle-income countries, including Iran. We evaluated the quality of life (QoL) in Iranian breast cancer patients who underwent BR at the Cancer Institute of Iran. We compared patients who had BR with breast cancer patients who had a radical mastectomy as the control group, matched for age, and time ...

Breast cancer is one of the most common malignancies among women in the United States. Based on 1,150 cases operated by the author, 56% of all operable breast cancers were treated either by radical mastectomy or extended mastectomy and 44% were treated by modified mastectomy during the 5 year period from 1974-1978. However, in 1985, 20% of the patients were treated by partial mas tectomy and ra...

OBJECTIVE The purpose of this study was to identify the clinicopathological characteristics and prognostic value of p53 overexpression in breast cancer patients treated with a modified radical mastectomy. METHODS The medical records of 197 patients who had undergone modified radical mastectomy between January 1991 and December 2008 were reviewed retrospectively. Breast cancer subtype and p53 ...

PURPOSE To improve the quality of life of patients who received modified radical mastectomy, we investigated the factors affecting health literacy (HL) and exercise adherence in postoperative breast cancer patients and analyzed the relationship between them. METHODS With random sampling method, we selected patients who received modified radical mastectomy in Nanjing First Hospital as research...

OBJECTIVE To obtain information about presenting features of women with breast cancer in Pakistan, to compare these data with information on patients with breast cancer in the United States and to highlight the differences. METHODS Patients referred to the National Cancer Institute, Karachi, Pakistan between January 1, 1994 and February 28, 1999 who had been recently diagnosed with breast can...

Preservation of the skin envelope and the inframammary fold is the main factor in achieving breast symmetry in unilateral reconstruction. Skin sparing mastectomy (SSM) type-IV followed by immediate autologous reconstruction and contralateral symmetrization permits realizing this goal in large, ptotic breasted patients, and tumor superficially located in the inferior quadrants. If the tumor is s...

BACKGROUND Breast-conserving surgery (BCS) plus radiotherapy is equivalent to modified radical mastectomy (MRM) in terms of outcome. However there is wide variation in mastectomy rates dependent both on tumour and patient characteristics. OBJECTIVE This study aimed to assess the determinants of surgery choice in Asian patients with early breast cancer in a middle-income country. MATERIALS A...