OBJECTIVE A substantial number of HIV infections worldwide are diagnosed at a late stage of disease. Mortality in late presenters is high, and their treatment is a specific challenge. We have determined the relative proportions of HIV-1 strains of different coreceptor tropism (CRT) in this group of patients and investigated the impact of CRT on progression markers such as CD4 cell counts and vi...

Mitigating the effects of changing climate with adaptable cultivars while reducing input burden additional selection criteria is becoming a priority, especially as water shortage limiting soybean production in Europe. To evaluate functionality photosynthetic apparatus drought, chlorophyll (Chl a) fluorescence was measured 16 elite lines drought and conditions sufficient supply V2 (second node),...

ion f belonging to such a set, for any ground theorem ', exists in 2 a proof 2 of the abstracted theorem f('); moreover exists (at least) one way to \map back" (at least one of the possible) 2 to 1 which gives rise to an outline of the ground proof. can be subsequently re ned. It is important to observe that in interactive abstract theorem proving there is no need to interact only with human be...

Intraneuronal protein aggregates of the mutated huntingtin in Huntington's disease (HD) brains suggest an overload and/or dysfunction of the ubiquitin-proteasome system (UPS). There is a general inhibition of the UPS in many brain regions (cerebellum, cortex, substantia nigra and caudate-putamen) and skin fibroblasts from HD patients. In the current experiment, the widely used mutant huntingtin...

CONTEXT: The indications for use of growth hormone (GH) have broadened with the availability of unlimited recombinant human growth hormone (rhGH). The FDA's approval for use of growth hormone in GH-sufficient patients with idiopathic short stature includes some children with constitutional delay of growth and puberty (CGD), a normal growth pattern variation which includes delayed puberty and pr...

During the HIV infection several quasispecies of the virus arise, which are able to use different coreceptors, in particular the CCR5 and CXCR4 coreceptors (R5 and X4 phenotypes, respectively). The switch in coreceptor usage has been correlated with a faster progression of the disease to the AIDS phase. As several pharmaceutical companies are starting large phase III trials for R5 and X4 drugs,...

conclusions thoracoscopic sympathicotomy shows proper results in treatment of phh. thoracoscopic r3-r5 sympathicotomy compared with r2-r4 sympathicotomy is a preferable method, because of similar results and fewer complications. objectives this study was planned to evaluate and compare complications and patients’ satisfaction of thoracoscopic sympathicotomy in levels of r2-r4 versus r3-r5 for p...

The aim of this study is to describe variability in the shape and amplitude of intensity profiles of anger episodes and how it relates to duration, and to investigate whether this variability can be predicted on the basis of appraisals and emotion regulation strategies used. Participants were asked to report on a wide range of recollected anger episodes. By means of K-spectral centroid clusteri...