The protein tubulin is central for maintaining normal cellular processes, and mol-ecules inter-fering with the tubulin dynamics have potential in the treatment of cancerous diseases. The title compound, C17H14N2O5, was prepared as a lead compound in a project dedicated to the development of therapeutic agents binding to the colchicine binding site on tubulin, thereby inter-fering with the cell ...

Natto is a traditional Japanese food made from soybeans fermented by strains of Bacillus subtilis natto. It gives off a strong ammonia smell during secondary fermentation, and the biochemical basis for this ammonia production was investigated in this study. When natto was fermented by strain r22, ammonia production was shown to involve degradation of soybean proteins releasing amino acids, and ...

The selection of lubricant is a key point in developing rotary compressor using R407C as a substitute for R22. The viscosity of oil, miscibility with refrigerant, thermal stability and compatibility with motor materials, etc, are all considerations. Furthermore, by reason of the POEs are more hygroscopic than mineral oils, hydrolytic stability and hygroscopicity of the selected oil must be cons...

Herein, three novel cocrystals of 1-hydroxy-2-naphthoic acid: tetramethylpyrazine, acid:1,10-phenanthroline, and acid:1,4-bis(imidazol-1-ylmethyl)benzene (L2) were obtained by crystallization in methanol–water mixed solvent via a slow evaporation method. The cocrystalline products 1−3 carried out range techniques, including single-crystal X-ray diffraction, Fourier transform–infrared spectrosco...

When the re:fiigerant R l34a is mixed with an ester oil and usea m compressor bearing lubrication, no EP action is experienced. The refrigerant contains no chlorine and the lubricant additives can not be chemically active like normal EP additives, not to deposit in and destroy the heat excha..>Jgers. The iubricant film thickness thus needs to be considerably larger for an Rl34a compressor beari...

The crystal structures of 6-meth-oxy-1,3-benzoxa-thiol-2-one, C9H8O3S, (I), and 2-oxo-1,3-benzoxa-thiol-6-yl acetate, C9H6O4S, (II), are described. Compound (I) is almost planar (r.m.s. deviation for the non-H atoms = 0.011 Å), whereas (II) shows a substantial twist between the fused-ring system and the acetate substituent [dihedral angle = 74.42 (3)°]. For both structures, the bond distances i...

In the title biphenyl derivative, C12H9N3O4, the dihedral angle between the benzene rings is 52.84 (10)°. The nitro group attached to the benzene ring is inclined to the ring by 4.03 (2)°, while the nitro group attached to the amino-substituted benzene ring is inclined to the ring by 8.84 (2)°. In the crystal, mol-ecules are linked by two pairs of N-H⋯O hydrogen bonds, forming chains propagatin...

Average Nusselt numbers were measured for R22, R290, R290/600a, and R32/152a undergoing evaporation and condensation in a brazed plate heat exchanger. The refrigerants experienced wavy, stratified flow at low heat and mass fluxes, 1.3 kW/m2 to 8.3 kW/m2 and 1.6 kg/m2 s to 19 kg/m 2 s, respectively. Heat transfer correlations from the literature for in-tube and channel flow of refrigerants with ...