Heterocyclic compounds have a wide range of applications, and Pictet–Spengler reaction is effectual in the synthesis heterocyclic such as quinoline isoquinoline. The present work describes an effective Pictet–Spengler-type protocol for selective quinoxaline derivatives from substituted pyrroles diverse aromatic aldehydes over tailored SnO2 nanoparticles anchored multi-walled carbon nanotubes (S...

In this study, a new series of quinoxalinone derivatives (5a–5p, 6a–6n) was designed and its hypoglycemic activity evaluated. The results showed that compounds 5i 6b exhibited stronger effects than the lead were comparable to positive control Pioglitazone. may exert by alleviating cellular OS modulating interactions among GLUT4, SGLT2, GLUT1 proteins. compound better 5i, found bind for most scr...

In this paper, we introduce Brønsted acidic ionic liquid (BAIL), (4-sulfobutyl) tris (4-sulfophenyl) phosphonium hydrogen sulfate as a green and efficient catalyst for the synthesis of 2,3-disubstituted quinoxaline derivatives via the one-pot condensation reaction of various o-phenylenediamine with 1,2-diketone derivatives. At all experiments, the desired products were synthesized successfully....

BACKGROUND Chagas' disease is a condition caused by the protozoan Trypanosoma cruzi that affects millions of people, mainly in Latin America where it is considered endemic. The chemotherapy for Chagas disease remains a problem; the standard treatment currently relies on a single drug, benznidazole, which unfortunately induces several side effects and it is not successful in the cure of most of ...

The principal aim of this research is the application of Fe3O4 (MNPs) in the synthesis of some indole derivatives. Fe3O4 MNPs were prepared by Co-Precipitation method from the reaction of FeCl2.4H2O and FeCl3.6H2O in ammonia solution. Morphology and structure of Fe3O4 MNPs were determined by FT-IR, X-Ray diffraction (XRD), transmission electron microscopy (TEM) and scanning electron microscopy ...

The high commercial demand for quinoxalines needs a rapid, greener and safer synthetic method among the chemists. A series of quinoxaline derivatives has been synthesized by condensation of diamines and dicarboniles in microwave heating conditions and in solvent free media. This environmentally benign synthetic approach gives us excellent yields (80-90%) in shorter reaction time (3.5 minutes.)....

The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Electrochemical and density functional studies demonstrate that coordination of electrolyte constituents to quinoxalines modulates their electrochemical properties. Quinoxalines are shown to be electrochemically inactive in most electrolytes in propylene carbonate, yet the pred...