1-(4-Morpholinomethyl)-tetrahydro-2(1H)-pyrimidinone (mopyridone) exhibited a marked activity against rubella virus (Judith and RA27/3 strains), a MIC50 value of 0.9 microM and selectivity ratio of 557.7 been found in the case of Judith strain. These data, in addition to the previous ones about its anti-alphavirus effects suggest the compound to be considered as a broad spectrum inhibitor of to...

Tetra-N-Butyl Ammonium Hydroxide was used as a catalyst for one-pot, three component condensation reactions consisting of aromatic aldehydes, malononitrile and barbituric acid in ethanol:water solvent system at 60oC. Current method has major advantages like mild reaction conditions with simple operation, high yields, by using a less toxic and lower costlier catalyst.In conclusion, we have explo...

Peptide nucleic acids containing 2-pyrimidinone (P) and 3-oxo-2,3-dihydropyridazine (E) heterocycles recognized C-G and U-A inversions in a polypurine tract of double helical RNA with high affinity and sequence selectivity at pH 6.25. E-modified PNA bound strongly to bacterial A-site RNA, while no binding was observed to the human A-site RNA.

In the title compound, C(20)H(15)N(3)O(2)·C(18)H(15)OP, the pyrimidinone heterocycle and the fused phenyl ring are inclined at 1.92 (7)°. Only the hy-droxy group is involved in hydrogen bonding, whereas the amino group is shielded from potential acceptors.

A new series of thienothiadiazolopyrimidinone 4 was prepared via the reaction of hydrazonoyl chlorides 2 with 2amino-tetrahydrobenzo[b]thiophene-3-carboxylic acid 1 followed by cyclization with 1,1`-carbonyldiimidazole. Furthermore, benzothienothiadiazolo pyrimidinone derivatives 11a-c were prepared. The structure of the newly synthesized compounds were established on the basis of spectral data...

High Internal Phase Emulsion hydrogels are prepared from waterborne poly(N-isopropylacrylamide) nanogel dispersions which are non-covalently crosslinked through 2-ureido-4[1H] pyrimidinone (UPy) quadruple hydrogen bond groups. The reversible UPy crosslinks allow for the HIPE-hydrogels to be molded into objects which are thermo-responsive in nature.

Pyrano [2,3-d] pyrimidinone derivatives have received considerable interest from the pharmaceutical industry due to their wide range of interesting biological and therapeutic properties. Nano Al2O3 was found to be a highly efficient solid acid catalyst for the preparation of pyrano [2,3-d] pyrimidinone derivatives from the reaction of barbituric acid, aryl aldehyde and mal...

The asymmetric unit of the title compound, C(12)H(14)N(2)O(4), contains two independent mol-ecules. In one independent mol-ecule, the furanyl fragment is rotationally disordered between two orientations in a 0.625 (6):0.375 (6) ratio. In the crystal, inter-molecular pyrimidine-pyrimidinone N-H⋯O hydrogen bonds link the mol-ecules into centrosymmetric tetra-mers, which are further associated int...

Pyrazole-based β-aminonitriles and β-amino-carbaldehydes as bifunctional building blocks are introduced in a facile copper(II)-catalysed one-pot domino generation of multiple N-containing heterobi- and tricycles. This streamlined synthetic approach permits easy access to novel pyrazole-fused imidazo- and pyrimido[1,2-c]pyrimidinones and to pyrazolo[3,4-d]pyrimidinone species with isolated yield...