Pemphigus foliaceus is a chronic autoimmune disease of the skin, clinically characterized by scaly and crusty cutaneous erosions involving the seborrheic areas. The patient can eventually become erythrodermic. There are reports of atypical cases of pemphigus foliaceus with pustules and neutrophils, and clinical differentiation from generalized pustular psoriasis of von Zumbusch is difficult. We...

Previous studies of acute generalized exanthematous pustulosis, a peculiar drug hypersensitivity reaction, suggested that CXCL8-producing T cells regulate sterile, polymorphonuclear neutrophil-rich skin inflammations. In this study, we test the hypothesis of whether CXCL8-producing T cells are present in autoinflammatory diseases like pustular psoriasis and Behçet's disease. Immunohistochemistr...

BACKGROUND Palmoplantar pustular psoriasis is often recalcitrant to therapy. Here we evaluated the therapeutic effect of alitretinoin in patients with recalcitrant palmoplantar pustular psoriasis and investigated subsequent immunopathological alterations. METHODS Seven patients with palmoplantar pustular psoriasis were treated with oral alitretinoin 30 mg once daily for 12 weeks. Efficacy was...

Sir, In 1968, Baker & Ryan. reported 5 patients with an exanthematic subtype of generalized pustular psoriasis (GPP) (1). The patients had developed a widespread and short-lived sterile pustular eruption either following an infection or for no apparent reason. They had no previous history of psoriasis. In 1980, Beylot et al. (2) introduced the term acute generalized exanthematous pustulosis (AG...

Treatment of von Zumbusch pustular psoriasis is a formidable task, especially when confounded by concomitant human immunodeficiency virus (HIV) infection. To our knowledge, this is the first report of successful use of a biologic agent to treat a patient with both von Zumbusch pustular psoriasis and HIV. Given the propensity of HIV to both trigger and exacerbate psoriasis and the potentially se...

Sir, Annular pustular psoriasis (APP) is a rare form of psoriasis characterized by gyrate, annular lesions with an erythematous, scaly, pustular margin (1). Although usually generalized, in some instances it appears as a localized form (2). We herein report a case of APP localized to the dorsa of feet of a 23year-old woman. She had a 4-year history of similar lesions on the same area, but there...

Sir, A generalized pustular eruption in an adult may be the presenting feature of viral infections, drug eruptions, psoriasis, subcorneal pustular dermatosis or impetigo herpetiformis. Rarely, generalized pustulation is a manifestation of secondary syphilis. We present here a case of secondary syphilis with a dramatic generalized eruption of pustules followed by impetiginous lesions. The classi...

Psoriasis is a chronic disease, characterized by erythematous scaly lesions, presented in eight different forms: plaques, guttate, pustular, erythrodermic, inverse, nail and scalp psoriasis, and psoriatic arthritis. Its development depends on genetic factors, external stimulus and immune response alteration.1 Proinflammatory cytokines such as TNF-alpha, IL-12 and 23 may also be involved. In the...

Psoriasis, a chronic, immune-mediated skin disease characterized by red, scaly plaques, affects approximately 0.3% of the population in Japan. The aim of this open-label study was to evaluate the long-term efficacy and safety of ixekizumab, a humanized, anti-interleukin-17A monoclonal antibody, in Japanese patients with plaque psoriasis (n = 78, including 11 psoriatic arthritis), erythrodermic ...