The absorption of non-steroidal anti-inflammatory drugs (NSAIDs) through the nasal epithelium offers an innovative opportunity in field pain therapy. Thanks to bonding chitosan mucosa and its permeability-enhancing effect, it is excellent choice formulate microspheres for increase drug bioavailability. aim our work includes preparation spray-dried cross-linked non-cross-linked chitosan-based de...

piroxicam, an anti-inflammatory drug, exhibits poor water solubility and flow properties, poor dissolution and poor wetting. consequently, the aim of this study was to improve the dissolution of piroxicam. microparticles containing piroxicam were produced by spray drying, using isopropyl alcohol and water in the ratio of 40:60 v/v as solvent system, and spray chilling technology by melting the ...

Piper betle L., more commonly known as betel or local name of Sirih, belongs to the family Piperaceae. Previous researches had shown that the leaves of P. betle possess tremendous beneficial effects including antimicrobial, antioxidant, anti-diabetic, wound healing and gastro-protective properties. This is due to the present of the two bioactive component; propenylphenols; which is the Hydroxyc...

Nasal drug delivery can be assessed by a variety of means and regulatory agencies, e.g., the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have published a set of guidelines and regulations proposing in vitro test methods for the characterization of nasal drug products. This article gives a summary of the FDA and EMA requirements regarding the determination of dropl...

In this paper, the babbitting of a bearing in boiler feed pump of an electromotor has been studied. These bearings have an important role in reducing the shut down times in the pumps, compressors and turbines. The most conventional method in babbitting is casting as a melting method. The comparison between thermal spray and casting methods in babbitting shows that the thermal spraying babbitt l...

Performance of compression ignition engine is known to be spray characteristics related. Precise experimental information on fuel sprays is of utmost importance to model the fuel spray formation and its development in the engine combustion chamber. The previous experimental work of the present author on non-evaporating sprays produced by using a FIAT single-hole orifice type nozzle and a distri...

Background: Reusable nasal-spray devices are frequently used in otolaryngologic examinations, and there is an increasing concern about the risk of cross-contamination from these devices. The aim of our study was to determine, by means of microbiologic analysis, the safety of a positivedisplacement or pump-type atomizer after multiple uses. Methods: A reusable nasal spray bottle, pump, and tips ...