OBJECTIVES To investigate clinical outcomes according to ventilatory support indication in subjects with chronic obstructive pulmonary disease exacerbation in a "real-life" Emergency Department and to analyze potential predictors of successful noninvasive positive pressure ventilation. METHODS Retrospective cohort performed over an 18-month period, comparing the following patient groups with ...

PURPOSE To assess the viability of oxygen-enhanced ventilation images using ultra-short echo time magnetic resonance imaging (UTE-MRI). METHODS We evaluated the oxygen enhancement of the pulmonary T2*, and pulmonary signals in each TE (0.2, 0.8, 1.4, 2.0 ms) in 21 nonsmokers. RESULTS The oxygen enhancement of pulmonary signals was the most significant (32%) at the 0.2 ms TE, the second in t...

BACKGROUND It has been proposed that partial liquid ventilation (PLV) causes a compression of the pulmonary vasculature by the dense perfluorocarbons and a subsequent redistribution of pulmonary blood flow from dorsal to better-ventilated middle and ventral lung regions, thereby improving arterial oxygenation in situations of acute lung injury. METHODS After induction of acute lung injury by ...

BACKGROUND The onset of ventilation at birth decreases pulmonary vascular resistance (PVR) resulting in a large increase in pulmonary blood flow (PBF). As the large cross sectional area of the pulmonary vascular bed develops late in gestation, we have investigated whether the ventilation-induced increase in PBF is reduced in immature lungs. METHODS Surgery was performed in fetal sheep at 105 ...

Six cases of massive pulmonary haemorrhage in newborn infants are described. 2 term infants suffered severe birth asphyxia and massive pulmonary haemorrhage presented early (mean 5 hours); in 4 preterm infants massive pulmonary haemorrhage presented late (mean 4 days) while receiving assisted ventilation. All the infants were treated with positive pressure ventilation, vigorous correction of pH...

BACKGROUND The impact of intraoperative ventilation on postoperative pulmonary complications is not defined. The authors aimed at determining the effectiveness of protective mechanical ventilation during open abdominal surgery on a modified Clinical Pulmonary Infection Score as primary outcome and postoperative pulmonary function. METHODS Prospective randomized, open-label, clinical trial per...

BACKGROUND Protective lung ventilation is recommended in patients with acute respiratory distress syndrome (ARDS) to minimize additional injuries to the lung. However, hypercapnic acidosis resulting from ventilation at lower tidal volume enhances pulmonary hypertension and might induce right ventricular (RV) failure. We investigated if extracorporeal veno-venous CO2 removal therapy could have b...

Partial liquid ventilation using conventional ventilatory schemes improves lung function in animal models of respiratory failure. We examined the feasibility of high-frequency partial liquid ventilation in the preterm lamb with respiratory distress syndrome and evaluated its effect on pulmonary and systemic hemodynamics. Seventeen lambs were studied in three groups: high-frequency gas ventilati...

Pulmonary capillary hemangiomatosis is a rare disease, characterized by small capillaries proliferation, leading to pulmonary hypertension. The authors report a case of pulmonary capillary hemangiomatosis, and discuss its diagnostic difficulties. Special attention is presented to ventilation/perfusion scintigraphy, given both its importance to the evaluation of pulmonary hypertension, and its r...