OBJECTIVE Pulmonary valve replacement is performed increasingly late after correction of Tetralogy of Fallot. Most reports deal with pulmonary allografts as the valvar substitute of choice, although late deterioration and reoperation(s) are the rule. Mechanical valves are scarcely reported and if so only because of complications. Although life-long anticoagulation therapy is indicated for mecha...

Spontaneous blood clotting in pulmonary circulation caused by thrombo-inflammation is one of the main mortality causes during COVID-19 disease. Blood leads to reduced and oxygenation. Lung inflammation can be evaluated with noninvasive diagnostic techniques. However, correlation severity flow has not been established. To address this question, work, we develop a multiscale model taking into acc...

Acute pancreatitis is an inflammatory disease characterized by local tissue injury which can trigger a systemic inflammatory response. Vascular complications of pancreatitis are a major cause of morbidity and mortality. Pulmonary embolism in acute pancreatitis has been reported to be very rare. Cardiovascular complications include shock, hypovolemia, pericardial effusion, and even nonspecific S...

A number of complications have been associated with ablation of atrial fibrillation (AF), including arterial thrombo-embolism, pulmonary vein stenosis, phrenic nerve injury, and pericardial tamponade.1–4 Esophageal injury, manifested as esophageal perforation or left atrial-esophageal fistula, has been reported after catheter or surgical ablation of AF using radiofrequency (RF) current5–8 and c...

sicca syndrome (dry eyes, dry mouth), pulmonary arterial hypertension/lung fibrosis, a variety of central and peripheral nervous system-related symptoms, and symmetric proximal muscle weakness and pain. Furthermore, proteinuria, hematuria, and recurrent pleuritis/pericarditis also belong to the disease spectrum of these disorders. Symptoms representing antiphospholipid syndrome (recurrent throm...

Among the spectrum of venous thrombo-embolic disease, acute pulmonary embolism accounts for the most life threatening manifestations with mortality exceeding 50%. It can affect many patient populations across various disciplines, hence immediate attention and aggressive treatment is crucial. With the advancement of technologies, various catheter-based devices are available to treat massive or s...

Low molecular weight heparin (LMWH), unfractionated heparin (UFH) and warfarin were compared with respect to efficacy and safety in the prevention of thrombo-embolism in general surgery. Meta-analysis (MA) with a priori definition of the MA protocol was used to combine the results from randomised trials with patients who underwent general surgery and deep-vein thrombosis (DVT) prophylaxis with ...

The case is described of a young man with probable familial antithrombin III deficiency, a disorder associated with a marked predisposition to venous thrombo-embolic events. In addition to a history of venous thrombosis and pulmonary embolism, at post-mortem this patient demonstrated widespread arterial thrombosis and atheroma. The probable association of severe arterial thrombosis and atheroma...