Acute pulmonary embolism (PE) is a common clinical condition with presentations that may vary from asymptomatic subsegmental emboli to massive vascular obstruction and shock with high risk of death. Identifying patients at highest risk for death is critical to select those who would benefit most from thrombolytic therapy. New and evolving clinical prediction models, serum tests, and imaging mod...

We read the article, entitled “Successful treatment of a pulmonary embolism with low-dose prolonged infusion of tissue-type plasminogen activator in a 37-year-old female in the early postoperative period,” by Aykan et al. (1) in Anatolian J Cardiol 2014; 14: 400-2. We believe that it can be a really good idea to administer low-dose thrombolytic agents in pulmonary embolism to minimize possible ...

OBJECTIVES We sought to assess the efficacy and safety of thrombolytic therapy in patients with an acute pulmonary embolism (PE). BACKGROUND Thrombolytic therapy is approved for the treatment of acute PE; however, the safety and efficacy of this therapy remain debated. METHODS A meta-analysis of randomized, controlled trials comparing thrombolytic agents with intravenous heparin in patients wit...

Sir, pulmonary emboli, weight-adjusted thrombolytic Acute pulmonary embolism is potentially fatal unless therapy was given. Patient 4 presented with syncope treated early. Thrombolytic therapy is beneficial for and shortness of breath. Electrocardiogram revealed patients with acute pulmonary embolism who are an S 1 O 3 T 3 pattern, and echocardiogram showed hypotensive and have arterial hypoxae...

a pulmonary embolus clogs the artery that provides blood supply to a part of the lung. the embolus not only prevents the exchange of oxygen and carbon dioxide but also decreases blood supply to the lung tissue itself, potentially causing the tissue to die (infarct). a 52-year-old man presented with syncope and anxiety. he had sinus tachycardia and dilated right ventricle with trabeculations. a ...

A case of massive pulmonary embolism complicated by acute cor pulmonale and shock is presented. The IV administration of recombinant tissue-type plasminogen activator (rt-PA) was associated with prompt reversal of clinical, ECG, and nuclear radiographic findings. The role of thrombolytic therapy with rt-PA for massive pulmonary embolism associated with hemodynamic decompensation deserves furthe...

Surgical embolectomy for pulmonary embolism and intracardiac thrombus is a rare but occasionally required procedure that should be considered when anticoagulation and/or thrombolytic therapy is contraindicated or failed. We describe a patient with massive pulmonary embolism and a large, mobile, snake-like thrombus in the right atrium, as well as a patent foramen ovale, treated successfully by s...

Right heart thrombus is a slightly detectable condition. In patients presenting with acute pulmonary embolism, the finding of thrombus in transit has been associated with high in-hospital mortality. We present a case of a 50-year-old male patient with acute pulmonary embolism and a thrombus in transit in the right atrium. We took the decision to perform fibrinolysis with tenecteplase, presentin...

The authors review the evidence behind the use of thrombolytic therapy in patients with massive or submassive pulmonary embolism. Concurrent heparin therapy and the management of bleeding episodes are also discussed.