Arterial Hypertension Pulmonary hypertension (PH) is a haemodynamic and pathophysiological condition defined as an increase in mean pulmonary arterial pressure (PAP) ≥25mmHg at rest, as assessed by right heart catheterisation. PH covers a heterogeneous group of clinical conditions and is classified (according to the most recent classification system defined during the fourth World Symposium on ...

Pulmonary arterial hypertension is an obstructive pulmonary vasculopathy and the RV considered a major determinant of survival in patients with precapillary hypertension. The transition from adaptive to maladaptive phenotype remains poorly understood clinically unpredictable. Several mechanisms having been suggested right heart disease but causes cardiac remodeling remain unknown require furthe...

pulmonary arterial hypertension (pha) is a frequent complication of congenital heart disease (chd), most commonly in systemic-to-pulmonary shunt lesions. in patients with an uncorrected left-to right shunt, pah will end up to eisenmenger’s syndrome, which is contraindication of surgery. what about patients with moderate to severe pah, who do not have criteria of eisenmenger’s syndrome; immediat...

Erythropoietin (EPO) mobilises endothelial progenitor cells and promotes neovascularisation in heart failure. The present authors studied the effects of EPO on pulmonary vascular and cardiac remodelling in a model for flow-associated pulmonary arterial hypertension (PAH). PAH was induced in adult male Wistar rats by the injection of monocrotaline combined with an abdominal aortocaval shunt 1 we...

Background 4D flow CMR analysis of main pulmonary artery (MPA) flow in pulmonary arterial hypertension (PAH) has demonstrated vortical formations whose existence time correlates with mean pulmonary arterial pressure (MPAP). Vorticity can quantitate the rotation of these vortices and may represent a novel way to assess pulmonary arterial hemodynamics. We aimed to determine if MPA vorticity corre...

Pulmonary arterial hypertension affects the distal pulmonary vasculature causing intimal, medial, adventitial fibrosis, thickening and periadventitial changes leading to progressive increase in pulmonary vascular resistance and pulmonary arterial pressure [1]. Pulmonary hypertension (PH) is defined as mean pulmonary artery pressure equal to or greater than 25 mm Hg at rest. PH is classified int...

an elevated pulmonary artery pressure (pap) from any cause is associated with increased mortality, especially in cases of primary pulmonary arterial hypertension (pah). one of the many reasons behind a bad prognosis is the inherent difficulty in assessing right ventricular (rv) function with reproducible methods. intensive research involving the left heart has made it relatively easy to assess ...

A pulmonary hypertension (PH) registry (Spanish Registry of Pulmonary Arterial Hypertension) was undertaken to analyse prevalence, incidence and survival of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) in Spain, and to assess the applicability of recent survival prediction equations. Voluntary reporting of previously diagnosed and incident PAH ...

Abstract Background Pulmonary arterial hypertension (PAH) is a progressive and severe rare disease. It pulmonary vasculature obstructive disease that leads to right heart failure death. circulation dysfunction endotelial characterized by vasoconstriction proliferation. Aim of study search possible correlations between peripheral endothelian function cardiopulmonary in patients with suspect PAH....

Pulmonary arterial hypertension (PAH) is a progressive disease that ultimately leads to right heart failure and death. PAH is defined as a mean pulmonary arterial pressure ≥ 25 mm Hg with a pulmonary capillary wedge pressure ≤ 15 mm Hg at rest. The diagnosis of PAH is one of exclusion; diagnostics include an extensive history, serology, chest radiograph, pulmonary function tests, ventilation/pe...