The Committee of Central Precocious Puberty Korean Pediatrics and Adolescents the Society Pediatric Endocrinology has newly developed evidence-based 2022 clinical practice guidelines for central precocious puberty in children adolescents. These provide grade recommendations, which includes both strength recommendations level evidence. In absence sufficient evidence, are based on expert opinion....

The initiation of mammalian puberty is underpinned by an increase in Kisspeptin (Kiss1) signaling via its receptor (Kiss1r/GPR54) on gonadotropin-releasing hormone (GnRH) neurons. Animals and humans with loss-of-function mutations in Kiss1 or Kiss1r fail to go through puberty. The timing of puberty is dependent on environmental factors, and malleability in puberty timing suggests a mechanism th...

BACKGROUND Assessment of pubertal stages should be related to updated and reliable referance data from the same background population. OBJECTIVE The aim of this study was to provide normative data for the onset and tempo of puberty in Turkish girls and analyze the growth parameters in puberty. METHODS The analyses are based on data that were collected and evaluated biannually on 1020 Turkis...

Thirty eight, chronic, perennial asthmatic children were prospectively examined every six months for a mean 8.9 years to clarify the relation between clinical asthma and puberty. Improvement in the disease occurred independent of puberty but the rate of improvement was appreciably greater during puberty. This led to speculation that improvement in childhood asthma could be associated with an im...

BACKGROUND Cross-sectional studies suggested that allergy prevalence in childhood is higher in boys compared to girls, but it remains unclear whether this inequality changes after puberty. We examined the sex-specific prevalence of asthma and rhinitis as single and as multimorbid diseases before and after puberty onset in longitudinal cohort data. METHODS In six European population-based birt...

BACKGROUND Precocious puberty, as early physical development and low final height might lead to psychosocial problems. OBJECTIVE To evaluate etiology and clinical feature of precocious puberty in a cohort of Iranian children. MATERIALS AND METHODS In this case-series study, 44 girls and 8 boys with precocious puberty referred to Endocrine Reserch Centre (Firouzgar), Institute of Endocrinolo...

Little is known about rates and predictors of remission of childhood asthma after the onset of puberty. We used data collected at ages 6, 8, 11, 13, and 16 years from the Tucson Children's Respiratory Study, a population-based birth cohort. The onset of puberty was defined as the age of appearance of the first pubertal signs as reported by parents. Information on wheezing both before and after ...