Neuropsychological impairment and abnormalities in brain structure are commonly observed in psychotic disorders, including schizophrenia and bipolar disorder. Shared deficits in neuropsychological functioning and abnormalities in brain structure suggest overlapping neuropathology between schizophrenia and bipolar disorder which has important implications for psychiatric nosology, treatment, and...

BACKGROUND The fourth edition of Diagnostic and Statistical Manual of Mental Disorders (DSM IV) distinguishes schizophrenia, schizophreniform disorder and brief psychotic disorder only according to the duration of the illness. Thus, the validity of these nosological concepts sounds uncertain. AIM The aim of this study was to evaluate the validity of the DSM IV concepts schizophrenia, schizoph...

BACKGROUND Personal space is the area individuals maintain around themselves into which others cannot intrude without arousing discomfort. The purpose of this study was to establish whether patients with anxiety disorder and patients with psychotic disorder differ in personal space preferences according to experimenter sex. SUBJECTS AND METHODS 82 patients who met the ICD- criteria for psycho...

Acute disseminated encephalomyelitis (ADEM) is a monophasic clinical syndrome, characterized by immune-mediated demyelination of central nervous system neurons, which yield extensive damage in the brain and spinal cord.It usually affects children and young adults following infections or immunization. Here we describe a 9- year-old Fars female presented with acute onset of psychotic disorder, o...

We describe a rare case of psychotic disorder, with unique family dynamics and management difficulties.

Background: Psychotic disorder due to industrial drug, such as methamphetamine addiction, is one of the important causes for referral to psychiatric hospital. Psychotic symptoms in these patients are varied. A group of researchers believe that methamphetamine-induced psychosis is completely similar to schizophrenia. Others believe that at least some cases of permanent psychotic clinical manifes...

BACKGROUND The identification of biomarkers of transition from the at-risk mental state (ARMS) to psychotic disorder is important because early treatment of psychosis is associated with improved outcome. Increasing evidence points to an inflammatory contribution to psychosis. We questioned whether raised levels of plasma inflammatory markers predict transition from ARMS to psychotic disorder an...

The relationship between obsessive compulsive disorder and psychotic state is intriguing. Early German authorities such as Bleuler shared the view put forward by Westphal that the entire obsessive compulsive syndrome is a variant or prodrome of Schizophrenia (Bleuler 1951). Many follow-up studies of patients who received an initial diagnosis of obsessive compulsive disorder have found variable ...

BACKGROUND There is evidence for microstructural white matter alterations in patients with psychotic disorder, suggesting altered interregional connectivity. Less is known about the presence and role of white matter alterations in well individuals at higher than average genetic risk for psychotic disorder. METHODS 85 patients with psychotic disorder, 93 non-psychotic siblings of patients with...