generalized pustular psoriasis with hypoparathyroidism has been reported previously often as a post thyroidectomy syndrome with hypoalbuminemia and hypocalcemia. but reports on association of pustular psoriasis with idiopathic hypoparathyroidism are very rare, and almost all of them occurred in patients with known psoriasis vulgaris. we report one of the youngest cases of this association in a ...

BACKGROUND CD39 and CD73 are two novel cell surface markers of CD25high Foxp3+ regulatory T-cells (Tregs). Concordant expression of these two ectoenzymes not only discriminate Tregs from other cell populations, but also generates pericellular adenosine, which has been reported to suppress proliferation of activated T effector (Teff) cells. Because it is currently unclear whether human ectoenzym...

BACKGROUND Psoriasis vulgaris is one of the most common chronic inflammatory skin disorders. Patients with psoriasis are at risk of developing atrial fibrillation (AF). The electromechanical delay (EMD) is the time interval from the onset of the P wave on surface electrocardiography (ECG) to the beginning of the A wave. Prolonged atrial EMD is an independent risk factor for the development of A...

BACKGROUND The methylenetetrahydrofolate reductase (MTHFR) enzyme catalyzes the reduction of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate and methyl donors. The methyl donors are required for the conversion of homocysteine to methionine. Mutation of MTHFR 677 C > T disrupts its thermostability therefore leads to defective enzyme activities and dysregulation of homocysteine levels...

The data presented in this article are related to the research article entitled "Cyr61/CCN1 is involved in the pathogenesis of psoriasis vulgaris via promoting IL-8 production by keratinocytes in a JNK/NF-κB pathway" (Pinru Wu, Gang Ma, Xianjin Zhu, Ting Gu, Jie Zhang, Yue Sun, Hui Xu, Rongfen Huo, Beiqing Wang, Baihua Shen, Xiangdong Chen, Ningli Li, 2016) [1]. Cysteine-rich 61 (Cyr61/CCN1), a...

Psoriasis, acne vulgaris and photoaging are common conditions. Tazarotene is a pro-drug of tazarotenic acid, a receptor-selective retinoid, which has shown efficacy in the treatment of these disorders. In the treatment of acne vulgaris, it has greater comedolytic activity than the currently available topical retinoids. In psoriasis, tazarotene normalizes keratinocyte differentiation, reverses k...

Myasthenia gravis is a rare autoimmune disorder in which antibodies form against acetylcholine nicotinic postsynaptic receptors at the myoneural junction. Psoriasis vulgaris is a chronic, recurring, and an inflammatory skin disease. Myasthenia gravis and psoriasis are both autoimmune diseases and correlated with specific human histocompatibility antigens. In this report, a 53-year-old woman who...

Psoriasis and pemphigus vulgaris are two inflammatory and autoimmune diseases. Their concomitant occurrence in one patient is very rare. We describe a 57-year-old patient with a history of severe plaque type psoriasis for 2 years. After a few months, he presented with disseminated bullae and mucosal erosions which were documented as pemphigus vulgaris. Both of the diseases were successfully con...

Oxidative stress is caused by an imbalance between the production of pro-oxidants and the capacity of a biological system of rapid detoxification of free radicals. In this paper the level of pro-oxidants and antioxidants was quantified in patients with psoriasis vulgaris. The results of this study show that the level of oxygen reactive species dramatically increases and the physiologic antioxid...

PsV: psoriasis vulgaris INTRODUCTION Pityriasis amiantacea is a rare clinical condition characterized by masses of waxy and sticky scales that adhere to the scalp and tenaciously attach to hair bundles. Pityriasis amiantacea can be associated with psoriasis vulgaris (PsV).We examined a patient with pityriasis amiantacea caused by PsV who also had keratotic horns on the scalp, histopathologicall...