Radiation dose escalation and acceleration improves local control but also increases toxicity. Proton radiation is an emerging therapy for localized cancers that is being sought with increasing frequency by patients. Compared with photon therapy, proton therapy spares more critical structures due to its unique physics. The physical properties of a proton beam make it ideal for clinical applicat...

In proton therapy, the dose from secondary neutrons to patient can contribute side effects and creation of cancer. A simple fast detection system distinguish between protons both in pretreatment verification as well potentially vivo monitoring is needed minimize neutrons. Two 3 mm long, 1 diameter organic scintillators were tested for candidacy be used a proton–neutron discrimination detector. ...

Background: Hadron therapy for malignant tumor is becoming increasingly popular. There are many factors which effect on implementation of a proper treatment planning. The purpose of this work is to investigate the inhomogeneity effects as affecting factor on proton range, Full width at half maximum (FWHM) and 20% position of penumbra (P20) by MCNPX code. Materials and Methods: An inhomogeneous ...

Charge particle therapy with 12 C ions has the advantage of an enhancement in physical dose distribution due to the Bragg Peak (BP) related to higher Relative Biological Effectiveness (RBE) with respect to X-ray radiotherapy and proton therapy (2.5 for 12 C ions and 1.1 for protons) [1], [2]. The RBE of a 12 C therapeutic beam changes dramatically with depth, especially towards the end of the S...

More and more camera concepts are being investigated to try and seize the opportunity of instantaneous range verification of proton therapy treatments offered by prompt gammas emitted along the proton tracks. Focusing on one-dimensional imaging with a passive collimator, the present study experimentally compared in combination with the first, clinically compatible, dedicated camera device the p...

0168-583X/$ see front matter 2010 Elsevier B.V. doi:10.1016/j.nimb.2010.10.013 ⇑ Corresponding author. E-mail addresses: [email protected], mortez [email protected] (M. Aslaninejad). Complete physical processes contributing to the shape of the depth-dose distribution and the so-called Bragg peak of proton beams passing through liquid water are given. Height, width and depth of the Bragg...

Background: Recent studies in eye plaque brachytherapy have shown a considerable difference between the dosimetric results using water phantom and a model of human eye containing realistic materials. In spite of this fact, there is a lack of simulation studies based on such a model in proton therapy literatures. In the presented work, the effect of utilizing an eye model with ocular media on pr...

Stereotactic ablative radiotherapy is being increasingly adopted in the treatment of lung tumors. The use of proton beam therapy can further reduce dose to normal structures. However, uncertainty exists in proton-based treatment plans, including range uncertainties, large sensitivity to position uncertainty, and calculation of dose deposition in heterogeneous areas. This study investigated the ...