نتایج جستجو برای: proton pump inhibitors

تعداد نتایج: 298233  

2016
Nihar Shah Yana Cavanagh Oleg Shulik Pooja Patel Vincent A. DeBari Walid Baddoura

Introduction: Inhaled & systemic steroids are one of the well-documented risks factors for Candida esophagitis. However, the role of gastric acid suppression remains controversial. Methods: We conducted a retrospective case-control study of 420 patients consisting of 84 cases of Candida esophagitis and 336 matched controls. Our cohort was gathered from subjects evaluated from 2001 to 2012. The ...

Journal: :Zhonghua xin xue guan bing za zhi 2009
Michael J Allen Pamela McLean-Veysey

The drug interaction between proton pump inhibitors and clopidogrel has been the subject of much study in recent years. Contradictory results regarding the effect of proton pump inhibitors on platelet reactivity and on clinical outcome in clopidogrel-treated patients have been reported in literature. Concomitant use of omeprazole and clopidogrel was found to decrease the exposure (AUC) to clopi...

2012
Ian J Douglas Stephen J W Evans Aroon D Hingorani Anthony M Grosso Adam Timmis Harry Hemingway Liam Smeeth

OBJECTIVE To measure the association between use of proton pump inhibitors and a range of harmful outcomes in patients using clopidogrel and aspirin. DESIGN Observational cohort study and self controlled case series. SETTING United Kingdom General Practice Research Database with linked data from the Myocardial Ischaemia National Audit Project (MINAP) and the Office for National Statistics (...

2015
Philip R. Cohen

BACKGROUND Sweet's syndrome, also referred to as acute febrile neutrophilic dermatosis, can either occur as an idiopathic disorder or associated with another condition, including cancer, or induced by exposure to a drug. Proton pump inhibitors selectively inhibit gastric parietal cell H+-K+-adenosine triphosphatase and are most commonly used for the treatment of gastroesophageal reflux disease....

Journal: :Alimentary pharmacology & therapeutics 2004
M Robinson

During the past two decades, enormous changes occurred in the management of gastric acid-related diseases. First, the histamine2-receptor antagonists were introduced, offering patients the first single-agent therapy that effectively reduced gastric acid secretion. Proton pump inhibitors became widely available in the early 1990s, and they generally appeared to be superior to the histamine2-rece...

Journal: :American family physician 2012
Paul W Ament Daniel B Dicola Mary E James

Proton pump inhibitors effectively treat gastroesophageal reflux disease, erosive esophagitis, duodenal ulcers, and pathologic hypersecretory conditions. Proton pump inhibitors cause few adverse effects with short-term use; however, long-term use has been scrutinized for appropriateness, drug-drug interactions, and the potential for adverse effects (e.g., hip fractures, cardiac events, iron def...

Journal: :The American journal of medicine 2011
Elaine W Yu Scott R Bauer Paul A Bain Douglas C Bauer

BACKGROUND Concerns have been raised about the risk of fractures with acid-suppressive medications, such as proton pump inhibitors and histamine(2)-receptor antagonists. METHODS This meta-analysis evaluated the association between proton pump inhibitor or histamine(2)-receptor antagonist use and fractures. We performed a systematic search of published literature (1970 to October 10, 2010) in ...

Journal: :Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 2015
Elena Villamañán Margarita Ruano Catalina Lara José Manuel Suárez-de-Parga Eduardo Armada Rodolfo Álvarez-Sala Ester Pérez Alicia Herrero

BACKGROUND Proton-pump-inhibitors are often prescribed unnecessarily in hospitals, which in turn induces their prescriptions after discharge. OBJECTIVE To evaluate patients starting treatment with proton-pump-inhibitors during hospitalisation and proportion of inappropriate prescriptions. Patient risk factors and whether initiation in hospital induced their continuation in ambulatory care wer...

Journal: :Cardiovascular Therapeutics 2010

Journal: :Polish Archives of Internal Medicine 2015

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