In 34 hepatocellular carcinoma patients (44 lesions), proton irradiation was performed and assessed. Proton irradiation was effective for the nodular HCCin terms of tumor size reduction and histology and almost 100%local tumor control was obtained during the observation period of at least 2 years, which is still undergoing up to 4 years. This therapy is safe and has the merit of excellent QOL d...

BACKGROUND Cellular responses to proton beam irradiation are not yet clearly understood, especially differences in the relative biological effectiveness (RBE) of high-energy proton beams depending on the position on the Spread-Out Bragg Peak (SOBP). Towards this end, we investigated the differences in the biological effect of a high-energy proton beam on the target cells placed at different pos...

With robust optimization for spot scanning proton therapy now commercially available, the ability exists to account for setup, range, and interfield uncertainties during optimization. Robust optimization is particularly beneficial for craniospinal irradiation (CSI) where the large target volume lends itself to larger setup uncertainties and the need for robust match lines can all be handled wit...

Particle radiotherapy such as proton and carbon ion has been producing promising clinical results worldwide. The purpose of this study was to compare metastatic capabilities of malignant tumor cells after irradiation with photon, proton, and carbon ion beams to clarify their ion beam-specific biological effects. We examined the biological properties of highly aggressive HT1080 human fibrosarcom...

Proton irradiation effects on strained Si 1.XGeX/Si heterostructures have been studied. For the experiment, p+-Sil -xGex/p--Si heterojunction diodes were fabricated by molecular beam epitax y (MBE) growth of strained p+boron doped SiGe layers on p -Si(100) substrates. Due to the valence band discontinuity between SiGe and Si layers, and degenerate doping in the SiGe layer, the characteristics o...

The effect of 53 MeV proton irradiation on the reliability silicon carbide power MOSFETs was investigated. Post-irradiation gate voltage stress applied and early failures in time-dependent dielectric breakdown (TDDB) test were observed for irradiated devices. drain during affects degradation probability by TDDB tests. Proton-induced single event burnouts (SEB) devices which biased close to thei...

BACKGROUND Considering that HTB140 melanoma cells have shown a poor response to either protons or alkylating agents, the effects of a combined use of these agents have been analysed. METHODS Cells were irradiated in the middle of the therapeutic 62 MeV proton spread out Bragg peak (SOBP). Irradiation doses were 12 or 16 Gy and are those frequently used in proton therapy. Four days after irrad...

Proton-induced absorption over the 280-700-nm region and growth of that coloring with increasing dosage of proton radiation were determined for three Schott glasses used as focusing elements in the International Ultraviolet Explorer. It was found that the absorption spectra for each glass can be fitted with three Gaussian shaped bands in the near UV-visible range, while a fourth Gaussian charac...

INTRODUCTION Proton radiation offers physical advantages over conventional radiation. Radiosensitivity of human 59M ovarian cancer and HTB140 melanoma cells was investigated after exposure to γ-rays and protons. MATERIAL AND METHODS Irradiations were performed in the middle of a 62 MeV therapeutic proton spread out Bragg peak with doses ranging from 2 to 16 Gy. The mean energy of protons was ...

0019-1035/$ see front matter 2010 Elsevier Inc. A doi:10.1016/j.icarus.2010.11.007 ⇑ Corresponding author. Fax: +1 434 924 1353. E-mail address: [email protected] (R.A. Baragiola). Remote infrared spectroscopic measurements have recently re-opened the possibility that water is present on the surface of the Moon. Analyses of infrared absorption spectra obtained by three independent space instrum...