نتایج جستجو برای: prothrombin
تعداد نتایج: 7054 فیلتر نتایج به سال:
OBJECTIVE Two different prothrombin variants, p.Arg596Leu and p.Arg596Gln, conferring antithrombin resistance to patients with venous thromboembolism have been recently reported. Here, we describe a novel substitution affecting Arg596 of prothrombin molecule (Arginine596 to Tryptophan or p.Arg596Trp or Arg221aTrp in the chymotrypsinogen numbering system or prothrombin Padua 2) in 2 Italian fami...
The conversion of plasma to serum results in a variable loss of the coagulase-reacting factor (C.R.F.) of the plasma. The C.R.F. loss is incurred during the process of prothrombin conversion: conditions which favor the most effective prothrombin conversion result in maximal C.R.F. loss, while factors which interfere with prothrombin conversion spare the C.R.F. In a system containing an adequate...
The mechanisms by which blood levels of prothrombin (PT) are regulated in the vitamin K-sufficient state are unknown. We have studied PT synthesis by Reuber H-35 rat hepatoma cells exposed to vitamin K and [3H]leucine in serum-free cultures. Administration to the culture system of exogenous bovine PT and rat PT was characterized by increases in endogenous PT synthesis and secretion of 2- and 3-...
We identified a novel mechanism of hereditary thrombosis associated with antithrombin resistance, with a substitution of arginine for leucine at position 596 (p.Arg596Leu) in the gene encoding prothrombin (called prothrombin Yukuhashi). The mutant prothrombin had moderately lower activity than wild-type prothrombin in clotting assays, but the formation of thrombin-antithrombin complex was subst...
The importance of non-prothrombin plasma and serum constituents in the physiological conversion of prothrombin to thrombin has been recognized only recently. A hemorrhagic disorder, called "parahemophilia" (Owren's disease), is associated with an elevated prothrombin time attributable to deficiency of a plasma component termed "Factor V" (1, 2). Inadequacy of plasma Ac-globulin, required for ra...
The bleeding tendency in acute chloroform intoxication is due to deficiency in both plasma fibrinogen and plasma prothrombin. If the disorder is mild, no bleeding occurs. However, the prothrombin falls to rather low levels, although the fibrinogen falls only moderately. A bleeding tendency may also be produced by giving small repeated doses of chloroform. In such experiments, the hemorrhagic te...
BACKGROUND Fibrinogen and prothrombin have been suggested to become rate limiting in trauma associated coagulopathy. Administration of fibrinogen is now recommended, however, the importance of prothrombin to patient outcome is unknown. METHODS We have utilized two trauma patient databases (database 1 n = 358 and database 2 n = 331) to investigate the relationship of plasma prothrombin concent...
background : we conducted the present study to investigate the frequency of prothrombin g20210a mutation among acute lymphoblastic leukemia patients and healthy individuals from western iran and to detect the possible association between this mutation and the risk of acute lymphoblastic leukemia in our population. methods : the studied groups consisted of 92 children with acute lymphoblastic le...
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