This research was originally published in Molecular & Cellular Proteomics. Huegel, S. and Depping, R. and Dittmar, G. and Rother, F. and Cabot, R. and Sury, M.D. and Hartmann, E. and Bader, M. Identification of importin alpha 7 specific transport cargoes using a proteomic screening approach. Mol Cell Proteomics; 2014, 13:1286-1298. © 2014 by The American Society for Biochemistry and Molecular B...

BACKGROUND Preterm Birth (PTB) is a major cause of neonatal mortality and morbidity. Women with Polycystic Ovary Syndrome (PCOS) are at high risk of PTB. There is a need for research studies to investigate the mechanisms linking PCOS and PTB, to facilitate screening, and develop novel preventative strategies. OBJECTIVE To list all the proteomic biomarkers of PTB and integrate this list with t...

Ovarian cancer frequently presents late, when chances for long-term survival are poor. The increased survival advantage for patients diagnosed with early-stage ovarian cancer suggests that screening to detect early-stage disease might have an impact on disease mortality. Attempts are being made to develop effective screening procedures for early ovarian cancer in symptom-free women, using a var...

OBJECTIVE The aim of this study is to identify potential biomarkers for fetal trisomy 21 from previous publications using proteomic techniques and examine the potential value of such biomarkers in early screening for this aneuploidy. METHODS This was a case-control study of 25 pregnancies with fetal trisomy 21 and 50 euploid controls undergoing first-trimester screening for aneuploidies by a ...

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by the production of autoantibodies to a broad range of self-antigens. Profiling the autoantibody repertoire using array-based technology has emerged as a powerful tool for the identification of biomarkers in SLE and other autoimmune diseases. Proteomic microarray has the capacity to hold large number of self-antig...