نتایج جستجو برای: proteome
تعداد نتایج: 17190 فیلتر نتایج به سال:
Abstract In higher plants, the xylem, which is crucial for water and nutrient transport, also contains a diverse proteome. The composition of xylem sap proteome responds dynamically to changes in environmental conditions. Important functions are maintenance structural integrity defense against invading pathogens. Knowledge on signals that trigger proteomic scarce. Better understanding these pro...
Finding the minimal set of gene functions needed to sustain life is of both fundamental and practical importance. Minimal gene lists have been proposed by using comparative genomics-based core proteome definitions. A definition of a core proteome that is supported by empirical data, is understood at the systems-level, and provides a basis for computing essential cell functions is lacking. Here,...
We present a stochastic model of proteolytic digestion of a proteome, assuming the distribution of parent protein lengths in the proteome, the relative abundances of the 20 amino acids in the proteome, and the digestion “rules” of the enzyme used in the digestion. We derived a closed form expression for the fragment mass distribution for a large class of enzymes including the widely used Trypsi...
Why do large positive earnings surprises occur? The literature often treats large earnings surprises as the exogenous event that precipitates subsequent stock price drift, but analyst expectations and earnings realizations are the result of conscious decisions made by analysts and managers. While neither analysts nor managers have an obvious incentive for an extreme deviation between expected a...
In cellular systems, biophysical interactions between macromolecules underlie a complex web of functional interactions. How biophysical and functional networks are coordinated, whether all biophysical interactions correspond to functional interactions, and how such biophysical-versus-functional network coordination is shaped by evolutionary forces are all largely unanswered questions. Here, we ...
Viruses interact with hundreds to thousands of proteins in mammals, yet adaptation 6 against viruses has only been studied in a few proteins specialized in antiviral defense. 7 Whether adaptation to viruses typically involves only specialized antiviral proteins or 8 affects a broad array of proteins is unknown. Here, we analyze adaptation in ~1,300 9 virus-interacting proteins manually curated ...
Recent advances in single-cell assays have focused attention on the fact that even members of a genetically identical group of cells or organisms in identical environments can exhibit variability in drug sensitivity, cellular response, and phenotype. Underlying much of this variability is stochasticity in gene expression, which can produce unique proteomes even in genetically identical cells. H...
The Human Proteome Organization has several major collaborative research initiatives, including the Plasma Proteome Project. A major feature of the HUPO World Congress in Munich in August 2005 was the release of the special issue of PROTEOMICS with 28 articles from the pilot phase of the Plasma Proteome Project. An open Workshop and a presentation in the closing plenary session of the congress ...
In the post-genome era, biologists have sought to measure the complete complement of proteins, termed proteomics. Currently, the most effective method to measure the proteome is with shotgun, or bottom-up, proteomics, in which the proteome is digested into peptides that are identified followed by protein inference. Despite continuous improvements to all steps of the shotgun proteomics workflow,...
Streptococcus equi subspecies ( S. ) is an opportunistic pathogen and a major causative agent of equine strangles, contagious respiratory infection in horses other equines. In this study, we provide the dataset associated with our research publication “ -derived extracellular vesicles as vaccine candidate against infections” [1]. We describe genomic differences between 4047 ATCC 39506 outline c...
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