Protein protein interactions are usually represented as interaction networks (graphs), where the proteins are represented as nodes and the connections between the interacting proteins are shown as edges. Proteins or interactions with high betweenness are considered as key connector members of the network. The interactions of a protein are dictated by its structure. In this study, we propose a n...

Biological complex networks, such as protein-protein interaction network (PPIN), represent the underlying living mechanisms in cell. Begin with the PPIN, distinct level modular organizations appear, like so-called network motifs, protein complexes and signal pathways. The network motifs defined as spandrels are highly clustered. Here, the motif clusters are divided into two categories, i.e. inn...

background alcoholic hepatitis (ah) is an acute manifestation of alcoholic liver disease with high mortality rates. objectives our aim was to study the molecular mechanisms of ah. materials and methods the differentially expressed genes (degs) in liver between ah and control cases were identified by analyzing the gse28619 microarray data using t-test. the kyoto encyclopedia of genes and genomes...

The increasing availability of large-scale protein-protein interaction (PPI) data has made it possible to understand the basic components and organization of cell machinery from the network level. Many studies have shown that clustering protein interaction network (PIN) is an effective approach for identifying protein complexes or functional modules. A significant number of proteins in such PIN...

Proteins are some of the building blocks of organisms. They usually perform their functions by interacting with each other and forming protein complexes. A protein-protein interaction network is a graph that consists of proteins as vertices and their interactions as edges. Protein-protein interaction network alignment is very important in identifying protein complexes and predicting protein fun...

In the near future, design of a new generation of drugs targeting proteins will be required. Considering the complex bond between the drug and protein, the structure and stability of the target protein should be considered. So far, a series of in vitro investigations have been conducted with the aim of predicting drug-biological medium interactions. In these studies, use of spectroscopic method...