نتایج جستجو برای: protein binding

تعداد نتایج: 1446869  

Journal: :iranian journal of cancer prevention 0
b fekry department of biochemistry, university of mysore, mysore-570 006, india m siddaiah department of biochemistry, university of mysore, mysore-570 006, india kp srinivas department of biochemistry, university of mysore, mysore-570 006, india rv nunna department of biochemistry, university of mysore, mysore-570 006, india sd banerjee tufts university school of medicine, boston, usa karuna kumar mortha department of biochemistry, university of mysore, mysore-570 006, india

background: analysis of human cancer serum has revealed the presence of high amounts of hyaluronan (hyaluronic acid, ha) when compared to human normal serum, it is well documented that ha and its receptors, known as hyaladherins (habps) are involved in matrix regulation, cell proliferation, migration and malignant tumour progression. these hyaladherins not only interact with hyaluronan at the m...

Journal: :journal of nutritional sciences and dietetics 0
hamideh pishva department of cellular, molecular nutrition, school of nutrition sciences and dietetics, tehran university of medical sciences, tehran, iran soltanali mahboob nutrition research center, tabriz university of medical sciences, tabriz, iran mohammadreza eshraghian department of epidemiology and biostatistics, school of public health, tehran university of medical sciences, tehran, iran

ba ckground: obesity is a consequence of the excessive accumulation of fat in adipose tissue which can result in significant morbidity and mortality. obesity is a major health problem in iran.  objective: the aim of this study was to investigate the  effects of  epa consumption on bmi  and  fasting blood sugar by fabp2 genotypes and pparα (leu162val, and g/c intron polymorphism) genotypes.   m ...

D AL- SAADI, WE SNEADER,

Generally, plasma proteins owe their binding capacity to the presence of aminoacid units which enter into intra- and intermolecular hydrophobic bonding with a diverse range of endo- and exogenous chemical substances. The intermolecular interactions between the hydrophobic areas of drug molecules and those of plasma proteins play an important role in drug-macromolecular complex formation and...

Human serum albumin (HSA) is the most abundant protein in the blood plasma. Molecular dynamics simulations of subdomain IIA of HSA and its complex with salicylic acid (SAL) were performed to investigate structural changes induced by the ligand binding. To estimate the binding affinity of SAL molecule to subdomains IB and IIA in HSA protein, binding free energies were calculated using the Molecu...

Journal: :physical chemistry research 0
nasrin - sohrabi assistant professor of phys. chemistry,academic member,payame noor university,shahin shahr,isfahan, iran nahid rasouli department of chemistry, payame noor university (pnu), 19395-3697, tehran, i.r.iran marziyeh raissi department of chemistry, payame noor university (pnu), 19395-3697, tehran, i.r.iran

abstractinteraction of ni complex(salen= n, n´-ethylene bis(salicylideneimine)) with hen egg-white lysozyme (hewl) was studied by absorption spectroscopy, competitive binding study and thermal denaturation study. the protein binding affinity of ni complex was found to be (3.0×103m−1). the binding plot obtained from the absorption titration data gives a binding constant of 2.4 (± 0.3)×103 m-1. i...

Journal: :journal of research in medical sciences 0
marjan tabesh atsa noroozi masood amini awat feizi sahar saraf?bank maryam zare

background: retinol?binding protein 4 (rbp4) is known to regulate lipid and glucose metabolism and insulin resistance. the influences of rbp4 on metabolic syndrome (ms) are still unclear. the purpose of this study is to evaluate the association between serum levels of rbp4 and ms components in first?degree relations of type 2 diabetic patients. materials and methods: this cross?sectional study ...

Journal: :iranian journal of allergy, asthma and immunology 0
hamid nawaz-tipu combined military hospital, khuzdar cantt, pakistan.

the object of this cross sectional study was to determine the hcv subtype 3a envelope protein binding affinity with human leukocyte antigen. envelope 1 (e1) protein is one of the structural proteins responsible for entering the cells through the receptors. the binding affinity of e1 protein epitopes to the selected human leukocyte antigen (hla) class i alleles was investigated using the compute...

Background: Denileukin diftitox (trade name, Ontak) is the first recombinant immunotoxin (IM), in which the binding domain of diphtheria toxin has been replaced by the amino acid sequence of human interleukin-2 (DT389IL-2) using genetic engineering. Purity, stability, and structural property of the protein are critical factors for the scale-up production of this fusion protein. In this IM, loca...

Journal: :iranian journal of microbiology 0
a madhour department of microbiology, university of kaiserslautern, paul-ehrlich str. 23, d-67663 kaiserslaute p maurer department of microbiology, university of kaiserslautern, paul-ehrlich str. 23, d-67663 kaiserslaute r hakenbeck department of microbiology, university of kaiserslautern, paul-ehrlich str. 23, d-67663 kaiserslaute

background and objectives: streptococcus pneumoniae, a major human pathogen, is closely related to the commensal species s. mitis and s. oralis. s. pneumoniae surface proteins are implicated in virulence and host interaction of this species, but many of them have recently been detected in s. mitis b6 in silico. we tested for the presence of such genes usinga set of eight s. mitis and eleven s. ...

Journal: :iranian journal of microbiology 0
fatemeh yarian department of biotechnology, school of medicine, shahid beheshti university of medical sciences, tehran ,iran. mojgan bandehpour department of biotechnology, school of advanced technologies in edicine, shahid beheshti university of medical sciences, tehran, iran andcellular and molecular biology research center, shahid beheshti university of medical sciences, tehran, iran. negar seyed department of immunotherapy and leishmania vaccine research, pasteur institute of iran, tehran, iran. bahram kazemi department of biotechnology, school of medicine, shahid beheshti university of medical sciences, tehran, iran and department of biotechnology, school of advanced technologies in medicine, shahid beheshti university of medical sciences, tehran, iran and cellular and molecular biology research center, shahid beheshti university of medical sciences, tehran, iran.

background and objective: neisseria meningitidis is a leading cause of meningitis and sepsis worldwide. the factor h binding protein (fhbp) is a key virulence factor of neisseria meningitidis that is able to selectively bind to human factor h, the key regulator of the alternative complement pathway, which it has important implications for meningococcal pathogene- sis and vaccine design. the aim...

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