background: fasciola hepatica is one of the most important helminthes parasites and triclabendazole (tcbz) is routinely used for treatment of infected people and animals. secreted protease enzymes by the f. hepatica plays a critical role in the inva-sion, migration, nutrition and the survival of parasite and are key targets for novel drugs and vaccines. the aim of study was to determine the pro...

[1] The U.S. Historical Climatology Network (HCN) database contains statistical adjustments that address historical changes in observation time at each observing station in the network. A paper in 2002 suggested that these adjustments cause HCN temperature trends to be ''spuriously'' warm relative to other datasets for the United States. To test this hypothesis, this paper evaluates the reliabi...

Results of the J = 1 − 0 HCN observations toward 34 bright far-infrared sources selected from the IRAS Point Source Catalog are reported. Together with 17 sources observed in this line earlier (Pirogov et al., 1996) they form a complete sample of the sources with flux densities S(100μm) > 500 Jy and δ > 0◦ in the outer Galaxy. The HCN data are compared with the HCO+, NH3, CS and CO data taken f...

We present high spatial resolution (5.1 × 2.7) Owens Valley Radio Observatory (OVRO) millimeter array observations of HCN (J=1-0) and HCO (J=10) emission in the inner 3 pc of the Galaxy (0.04 pc ∼ 1). The HCN and HCO emission of the Circumnuclear Disk (CND) is distributed in a well-defined ring with a peak at a radius of 1.6 pc. The observed radial velocities are generally consistent with rotat...

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the HCN channel family comprises four members (HCN1-4) that are expressed in heart and nervous system. The current produced by HCN channels has been known as I(h) (or I(f) or I(q)). I(h) has also been designated as pacemaker c...

HCN channels play a unique role in bilaterian physiology as the only hyperpolarization-gated cation channels. Their voltage-gating is regulated by cyclic nucleotides and phosphatidylinositol 4,5-bisphosphate (PIP2). Activation of HCN channels provides the depolarizing current in response to hyperpolarization that is critical for intrinsic rhythmicity in neurons and the sinoatrial node. Addition...

Hydrogen cyanide (HCN) has been identified in the gas phase of the interstellar medium as well as in the comae of several comets. Terrestrially, HCN is a key component in the synthesis of biologically important molecules such as amino acids. In this paper, we report the results of low-temperature (18 K) ice energetic processing experiments involving pure HCN and mixtures of HCN with H2O and NH3...

Theoretical and computational frameworks for synaptic plasticity and learning have a long and cherished history, with few parallels within the well-established literature for plasticity of voltage-gated ion channels. In this study, we derive rules for plasticity in the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, and assess the synergy between synaptic and HCN channel pla...

Hyperpolarization-activated cation (HCN) channels give rise to an inward current with similar but not identical characteristics compared with the pacemaker current (I(f)), suggesting that HCN channel function is modulated by regulatory beta-subunits in native tissue. KCNE2 has been proposed to serve as a beta-subunit of HCN channels; however, available data remain contradictory. To further clar...

We present new HCN and HCO + ( J = 3–2) images of the nearby star-forming galaxies (SFGs) NGC 3351, 3627, 4321. The observations, obtained with Morita ALMA Compact Array, have a spatial resolution ∼290–440 pc resolve inner R gal ≲ 0.6–1 kpc targets, as well southern bar end 3627. complement this data set publicly available lower excitation lines HCN, , CO analyse behaviour representative line r...