Efficient reactions between fluorine-functionalised biphenyl and terphenyl derivatives with catechol-functionalised terminal groups provide a route to large, discrete organic molecules of intrinsic microporosity (OMIMs) that provide porous solids solely by their inefficient packing. By altering the size and substituent bulk of the terminal groups, a number of soluble compounds with apparent BET...

Bicyclo[1.1.1]pentylamines (BCPAs) are of growing importance to the pharmaceutical industry as sp3-rich bioisosteres anilines and N-tert-butyl groups. Here we report a facile synthesis 1,3-disubstituted BCPAs using twofold radical functionalization strategy. Sulfonamidyl radicals, generated through fragmentation ?-iodoaziridines, undergo initial addition [1.1.1]propellane afford iodo-BCPAs; new...

Strategies commonly used for the synthesis of functionalised bicyclo[1.1.1]pentanes (BCP) rely on reaction [1.1.1]propellane with anionic or radical intermediates. In contrast, electrophilic activation has remained a considerable challenge due to facile decomposition BCP cations, which severely limited applications this strategy. Herein, we report in halogen bond complex, enables its electron-n...

The bond energy (BE) of CC in CH3-CH3 with respect to geometry frozen fragments follows a sigmoidal increase as function the θ = HCC pyramidalization angle. Using dynamic orbital forces BE index, same behaviour unique 〈θ〉 parameter, mean angle substituents, is found for 24 single bonds various hydrocarbons. Thus parameter appears straightforward and robust index geometrical constraints which ca...

Expedient synthetic approaches to the highly functionalized polycyclic alkaloids communesin F and perophoramidine are described using a unified approach featuring a key decarboxylative allylic alkylation to access a crucial and highly congested 3,3-disubstituted oxindole. Described are two distinct, stereoselective alkylations that produce structures in divergent diastereomeric series possessin...

Design of some crystal and quasicrystal networks, based on rhombellane tiling,is presented. [1,1,1]Propellane,is a synthesized organic molecule; its hydrogenated form, the bicyclo[1.1.1]pentane,may be represented by the complete bipartite graph K2,3 which is the smallest rhombellane. Topology of translational and radial structures involving rhombellanes is described in terms of vertex symbol, c...