although the epileptogenic properties of estrogens have been widely demonstrated in several models and species, the mechanism(s) by which estrogens can acutely change seizure parameters including after discharge and seizure duration remain remains to be determined. in the present study, we examined the role of nmda (n-methyl-d-aspartate), non-nmda and estrogenic receptors in estradiol benzoate ...

BACKGROUND Prolongation of the corrected QT (QTc) interval is a key issue for patients who receive psychotropic medications. Such patients may have baseline clinical risk factors for QTc prolongation, and many psychotropic medications may further prolong this interval. This has great clinical relevance, as QTc prolongation is linked with dangerous arrhythmias, especially torsades de pointes (Td...

Drug-induced QT prolongation is a serious clinical issue in developing novel drug candidates and marketing drugs. A major cause of QT prolongation is direct inhibition of human ether-à-go-go-related gene (hERG) channels. Reduction in repolarization-related channel expression levels on plasma membranes is another mechanism that induces QT prolongation. Recently, we established a system for asses...

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Preventing cardiac deaths remains one of the greatest challenges in medicine in the 21st Century. There is evidence to suggest QT peak prolongation identi�ies patients who are at risk of death or non-fatal myocardial infarction (MI) [1]. The next step to reduce the risk of these patients would be to �ind out whether there are potentially treatable conditions associated with QT peak prolongation...

Prolongation of QTC is an electrocardiographic finding indicating prolongation of cardiac repolarization, which increases the risk for torsades de pointes, a form of ventricular tachycardia that can lead to sudden cardiac death. Sudden cardiac death in the setting of antipsychotic treatment was first described in the 1960s with thioridazine; since that time, many other psychotropic medications ...