Prolactin is best known as the polypeptide anterior pituitary hormone, which regulates the development of the mammary gland. However, it became clear over the last decade that prolactin contributes to a broad range of pathologies, including breast cancer. Prolactin is also involved in angiogenesis via the release of pro-angiogenic factors by leukocytes and epithelial cells. However, whether pro...

1) The evidence for a role of prolactin in the premenstrual syndrome is discussed in this review. (2) The timing of the onset and offset of both physical and psychological dysphoric symptoms corresponds with the luteal elevation and menstrual decrease of serum prolactin levels. (3) Women with premenstrual symptoms have been shown to have high prolactin levels throughout the menstrual cycle and ...

Since anterior pituitary expresses prolactin receptors, prolactin secreted by lactotropes could exert autocrine or paracrine actions on anterior pituitary cells. In fact, it has been observed that prolactin inhibits its own expression by lactotropes. Our hypothesis is that prolactin participates in the control of anterior pituitary cell turnover. In the present study, we explored the action of ...

Pituitary prolactin has been quantified by radioimmunoassay in whole milk obtained from cattle, goats, sheep and rats. Prolactin concentrations in milk samples obtained following the completion of lactogenesis approximate concentrations of the hormone in blood plasma or serum. However, concentrations of prolactin in prepartum mammary secretions were much higher than plasma prolactin in prepartu...

Objetives. To determine the correlation between prolactin levels and disease activity classified based on Mexican lupus erythematosus systemic index (MEX SLEDAI). Methods. In this cross-sectional observational study, serum prolactin, age, sex, treatment, as well manifestations of active were determined. Disease was evaluated using Systemic Lupus Erythematosus Activity Index (MEX-S...

Hyperprolactinaemia is one of the most frequent causes anovulation, resulting in infertility and hypoestrogenic state with consequences on overall women’s health. Recent investigations biological actions prolactin, especially prolactin extrapituitary origin, expand our knowledge role human organism open new questions connected female reproductive function treatment infertility. This article rep...

Familial Isolated pituitary adenoma (FIPA) is a rare cause of and underscores the importance family history knowledge screening guidelines in these patients. A 26-year-old female presented with secondary amenorrhea, galactorrhea, headaches dizziness. Labs showed Prolactin 501 ng/ml (3.3-26.7 ng/mL) IGF 391 (96-301 ng/mL). MRI brain 12 x 14 15 mm mass. Acromegaly was confirmed glucose suppressio...

Chamomile is a fascinating plant quoted in several traditional medicine texts, which hasbroad-spectrum pharmacological activity and medicinal uses. The aim of this study was toassess the efficacy of chamomile syrup in reducing serum prolactin in women with idiopathichyperprolactinemia. The study was a randomized, controlled clinical trial that was cond...

Prolactin - a hormone secreted in a circadian rhythm acts as a regulator of growth and development of the mammary glands. It has been observed that working at night increases breast cancer risk in women. Night shift work, probably carcinogenic to humans (Group 2A IARC), can disrupt a circadian rhythm, and thus potentially alter the rhythm of prolactin secretion. The aim of our work was to revie...