961 described in SSc patients with pulmonary fibrosis's or by spontaneous release of interleukin-1 since these alterations may enhance T helper cell function in antibody synthesis. This report emphasizes that antinuclear anti-Scl-70 antibodies may distinguish not only the diffuse cutaneous subset of SSc, but also patients at risk ofdeveloping severe lung disease. REFERENCES 1 Fritzler NJ, Kinse...

As a measure of enterocyte function, the deconjugation of pteroyl-L-glutamyl-y-Lglutamyl-y-L-glutamic acid to folic acid and subsequent active absorption was measured in 19 patients with progressive systemic sclerosis and compared with 14 controls. The absorption step of folic acid was identical in the two groups, while deconjugation of pteroyl-L-glutamyl-y-L-glutamyly-L-glutamic acid was signi...

Systemic sclerosis is a disease of unknown origin characterized by excessive deposition of collagen and other connective tissue macromolecules in skin and multiple internal organs, prominent and often severe alterations in the microvasculature, and humoral and cellular immunologic abnormalities (see Glossary). Systemic sclerosis is a complex and heterogeneous disease. Clinical forms range from ...

A clinical case of the development rapidly progressive systemic sclerosis after repeated coronavirus infection is described. The contribution occupational hazards, oncological process and radiation therapy to pathogenesis this disease discussed. Hydropericardium was a feature picture, as well rare immunological markers late onset sclerosis.