This paper discovers a distinct calendar anomaly on the US stock market associated with Groundhog Day prognostication tradition across 1928–2021. There are significant positive abnormal returns around “prediction” of an early spring, while buy-and-hold long winter 2.78% lower. The results robust in subsamples, to set placebo tests for international indices, and cannot be explained by January ef...

BACKGROUND In Asia, up to 25% of breast cancer patients present with distant metastases at diagnosis. Given the heterogeneous survival probabilities of de novo metastatic breast cancer, individual outcome prediction is challenging. The aim of the study is to identify existing prognostic models for patients with de novo metastatic breast cancer and validate them in Asia. MATERIALS AND METHODS ...

Tissue perfusion plays a critical role in oncology because growth and migration of cancerous cells require proliferation of new blood vessels through the process of tumor angiogenesis. Computed tomography (CT) perfusion is an emerging functional imaging modality that measures tissue perfusion through dynamic CT scanning following intravenous administration of contrast medium. This noninvasive t...

PURPOSE To offer evidence-based clinical recommendations concerning prognosis in advanced cancer patients. METHODS A Working Group of the Research Network of the European Association for Palliative Care identified clinically significant topics, reviewed the studies, and assigned the level of evidence. A formal meta-analysis was not feasible because of the heterogeneity of published studies an...

PURPOSE Malignant pleural mesothelioma (MPM) is a highly lethal neoplasm with limited pretreatment prognostication strategies. In this report, we examine the accuracy of a previously proposed prognostic test in an independent cohort of MPM patients. This test uses simple ratios of gene expression levels to provide a novel prognostication scheme. EXPERIMENTAL DESIGN Gene expression data using ...

Renal cell carcinoma (RCC) accounts for 2% of all new cancer cases worldwide. Staging systems for RCC are a valuable tool for guiding patient selection for the various treatment regimens and clinical trials. Integration of pathologic tumour stage with histologic and clinical features has led to the development of a number of comprehensive prognostication systems to predict patient outcomes. Mor...

Invasive, clinically non-metastatic bladder cancer has a cure rate of only 50%, when all T stages are considered. The pattern of relapse is dominated by systemic spread, provided that optimal surgery is practiced. Occult metastases are thus most likely to be present at first presentation. For more than 30 years, therapeutic strategies have focused on the use of systemic chemotherapy before, dur...

BACKGROUND Acute-on-chronic liver failure (ACLF) is characterised by a sudden deterioration of underlying chronic liver disease, resulting in increased rates of mortality and liver transplantation. Early prognostication can benefit optimal allocation of resources. METHODS ACLF was defined as per the disease criteria of the Asian Pacific Association for the Study of the Liver. Inpatient discha...