introduction: the aim of this study was to setup, optimize and introduce a sensitive and specific pcr detection method for identification of neisseria meningitidis dna in clinical samples. material and methods: capsular transport gene a (ctra) was selected as a specific target sequence. this primer pair amplifies 101bp of the target gene. neisseria meningitidis strain: atcc; 13090 and neisseria...

The mandatory upper frequency limit for radiated immunity testing on modules is increasing to 2.7GHz and for some dedicated product standards even up to 3GHz. This paper proposes a realistic limit level for using the Bulk Current Injection method as an alternative to radiated immunity tests up to 1GHz and above.

I propose a method for studying the product of bandwidths for the Harper-Hofstader model. This method requires knowledge of the moments of the midband energies. I conjectured a general formula for these moments. I computed the asymptotic representation for the product of bandwidths in the limit of a weak magnetic flux using Szegö’s theorem for Hankel matrices. I then give a first approximation ...

In this paper, we consider the product-limit quantile estimator of an unknown quantile function under a censored dependent model. This is a parallel problem to the estimation of the unknown distribution function by the product-limit estimator under the same model. Simultaneous strong Gaussian approximations of the product-limit process and product-limit quantile process are constructed with rat...

In recent years, cleaning validation has achieved a position of increasing in the pharmaceutical industry. It provides assurance to the cleaning procedure that ensures equipment is consistently cleaned from the product, detergent and microbial residues to an acceptable level to avoid cross-contamination and adulteration of drug product with other active ingredients. The aim of this study was to...

Olmesartan medoxomil (OLME) belongs to a group of angiotensin II receptor blockers used as an antihypertensive agent and is currently being used for prevention of hypertension. This paper describes the validation and development of stability indicating RP-HPLC method for the determination of OLME in the presence of its degradation products generated from forced degradation study and characteriz...

Objective: This study was designed to develop and validate a new reversed-phase high-performance liquid chromatography (RP-HPLC) method based on Q2 (R1) International Conference on Harmonization (ICH) guideline for determination of curcumin in pharmaceutical samples. Materials and Methods: The HPLC instrument method was optimized with isocratic elution with acetonitrile: ammonium acetate (45:55...

During the "Standards Development and International Harmonization: AOAC INTERNATIONAL Mid-Year Meeting" held on June 29, 2011, an Expert Review Panel (ERP) on behalf of AOAC INTERNATIONAL adopted the method "Simultaneous Determination of Vitamins D2 and D3 by LC-MS/MS in Infant Formula and Adult Nutritionals" as an AOAC Official First Action method. Vitamins D2 and D3 are extracted from the sam...

Process capability of a process is defined as inherent variability of a process which is running under chance cause of variation only. Process capability index is measuring the ability of a process to meet the product specification limit. Generally process capability is measured by 6 assuming that the product characteristic follows Normal distribution. In many practical situations the product ...