نتایج جستجو برای: proapoptotic gene

تعداد نتایج: 1144687  

Journal: :Carcinogenesis 2004
Jong Woo Lee Young Hwa Soung Su Young Kim Suk Woo Nam Chang Jae Kim Yong Gu Cho Jong Heun Lee Hong Sug Kim Won Sang Park Sang Ho Kim Jung Young Lee Nam Jin Yoo Sug Hyung Lee

Evidence exists that deregulation of apoptosis is involved in the mechanisms of cancer development, and the somatic mutations of apoptosis-related genes have been reported in human cancers. Bcl-XL/Bcl-2-associated death promoter (Bad), a proapoptotic member of Bcl-2 family, plays an important role in the intrinsic apoptosis pathway. To explore the possibility that the genetic alterations of Bad...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2002
Yi Ding Yong Wen Bill Spohn Li Wang Weiya Xia Ka Yin Kwong Ruping Shao Zheng Li Gabriel N Hortobagyi Mien-Chie Hung Duen-Hwa Yan

PURPOSE AND EXPERIMENTAL DESIGN p202, a mouse IFN-inducible protein, is a member of the 200-amino acid repeat family. Enforced p202 expression in stable cancer cell lines resulted in growth inhibition in vitro and tumor suppression in vivo. However, to study the immediate effect of p202 and test the potential efficacy of p202 treatment, an efficient gene delivery system for p202 is required. Fo...

Journal: :Molecular cancer therapeutics 2008
Ling Wang Qi Zhang Bin Liu Mei Han Baoen Shan

Livin is a member of the inhibitors of apoptosis protein gene family, which is highly expressed in a variety of human neoplasms. Several studies have shown that down-regulation of Livin expression increases the apoptotic rate, reduces tumor growth potential, and sensitizes tumor cells to chemotherapeutic drugs. Furthermore, emerging data reveal that Livin fragments cleavaged by caspases restore...

Journal: :Molecular and cellular biology 2002
Chengzhen Ren Likun Li Alexei A Goltsov Terry L Timme Salahaldin A Tahir Jianxiang Wang Laura Garza A Craig Chinault Timothy C Thompson

We identified a novel mouse gene, mRTVP-1, as a p53 target gene using differential display PCR and extensive promoter analysis. The mRTVP-1 protein has 255 amino acids and differs from the human RTVP-1 (hRTVP-1) protein by two short in-frame deletions of two and nine amino acids. RTVP-1 mRNA was induced in multiple cancer cell lines by adenovirus-mediated delivery of p53 and by gamma irradiatio...

Journal: :Journal of virology 2006
Angharad M Shore Paul C White Rosaline C-Y Hui Abdelkader Essafi Eric W-F Lam Martin Rowe Paul Brennan

Epstein-Barr virus (EBV) infection is associated with the development of many B-cell lymphomas, including Burkitt's lymphoma, Hodgkin's lymphoma, and posttransplant lymphoproliferative disease. The virus alters a diverse range of cellular molecules, which leads to B-cell growth and immortalization. This study was initiated to investigate the interplay between EBV and a proapoptotic transcriptio...

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