Psoriasis primarily affects the skin, but also has a systemic dimension and is associated with severe comorbidities. Since endothelial cells play an important role in psoriasis as well as in the development of cardiovascular comorbidities, we investigated whether a common mechanism, namely cytokine-induced insulin resistance, underlies both pathologies. Activation of the insulin pathway was stu...

BACKGROUND The proton-activated G protein-coupled receptor GPR4 is expressed in many tissues including white adipose tissue. GPR4 is activated by extracellular protons in the physiological pH range (i.e. pH 7.7 - 6.8) and is coupled to the production of cAMP. METHODS We examined mice lacking GPR4 and examined glucose tolerance and insulin sensitivity in young and aged mice as well as in mice ...

PURPOSE To investigate the mechanisms underpinning modifications in glucose homeostasis and insulin sensitivity 24 h after a bout of resistance exercise (RE) with or without protein ingestion. METHODS Twenty-four healthy males were assigned to a control (CON; n = 8), exercise (EX; n = 8) or exercise plus protein condition (EX+PRO; n = 8). Muscle biopsy and blood samples were obtained at rest ...

Recently we showed that fructose feeding in rats induced nonproteolytic activation of prorenin and subsequent angiotensin II production in skeletal muscle. In addition, a pharmacological inhibitor of prorenin/(pro)renin receptor interaction attenuated the development of insulin resistance. However, the inhibitor did not ameliorate the glucose intolerance in transgenic rats overexpressing the hu...

The transcription of many genes involved in lipid metabolism is regulated by the peroxisome proliferator– activated receptor-g (PPAR-g). The Pro12Ala polymorphism in the PPAR-g2 gene has been associated with reduced transcriptional activity in vitro and increased insulin sensitivity in vivo. Although PPAR-g has been demonstrated in human b-cells, it is unknown whether the Pro12Ala polymorphism ...

Ischemia-driven islet isolation procedure is one of the limiting causes pancreatic transplantation. Ischemia-reperfusion process associated with endothelium dysfunction and release pro-senescent microvesicles. We investigated whether endothelial microvesicles prompt senescence in vitro. Pancreatic islets were isolated from male young rats. Replicative was induced by serial passaging primary por...

Obesity and its associated metabolic diseases are one of the greatest public health challenges in the United States. Insulin resistance, a central and defining feature of obesity, has been identified as a primary contributor to the increase in many metabolic diseases including type 2 diabetes, cardiovascular disease, and hypertension. Currently, obesity-induced insulin resistance is proposed to...

To examine the effect of carbohydrate and/or protein supplements on the hormonal state of the body after weight-training exercise, nine experienced male weight lifters were given water (Control) or an isocaloric carbohydrate (CHO; 1.5 g/kg body wt), protein (PRO; 1.38 g/kg body wt), or carbohydrate-protein (CHO/PRO; 1.06 g carbohydrate/kg body wt and 0.41 g protein/kg) supplement immediately an...