نتایج جستجو برای: pri ring
تعداد نتایج: 126131 فیلتر نتایج به سال:
UNLABELLED MicroRNAs are a new class of small non-protein-coding RNAs that sometimes function as tumor suppressors or oncogenes. Aberrant expression and structural alteration of microRNAs have been reported to be involved in tumorigenesis and cancer development. Recently, rs531564/pri-miR-124-1, rs4938723/pri-miR-34b/c, rs7372209/pri-miR-26a-1, rs895819/pre-miR-27a, and rs11134527/pri-miR-218 w...
Povzetek. Članek opisuje vpliv kvantizacijske stopnice na kakovost digitalnega videa pri transformacijskem kodiranju videosignala. Transformacijsko kodiranje smo izvedli enkrat s pomočjo diskretne kosinusne transformacije (DCT) in drugič z diskretno valčno transformacijo (DWT). Kodeka DCT in DWT smo implementirali v programskem paketu Matlab-Simulink. Simulirali smo vpliv kvantizacije na kakovo...
Previous studies in vivo reported that processing of primary microRNA (pri-miRNA) is coupled to transcription by RNA polymerase II (RNAP II) and can occur co-transcriptionally. Here we have established a robust in vivo system in which pri-miRNA is transcribed by RNAP II and processed to pre-miRNA in HeLa cell nuclear extracts. We show that both the kinetics and efficiency of pri-miRNA processin...
Introduction: Risk management is the most part of health and safety executive (HSE) management systems and it can be used to identify dangers as well as prioritize actions to relieve dangers. Dangers identifying and evaluating risk scores of the dangers are two steps of the risk management that lead to prioritize identified dangers and help decision makers to allocate the necessary resour...
1α,25-dihydroxyvitamin D₃ (1,25D3) is a powerful differentiation inducer for acute myeloid leukemia (AML) cells. However, 1,25D3 doses required for differentiation of AML cells may cause lethal hypercalcemia in vivo. There is evidence that vitamin D₂ is less toxic than vitamin D₃ in animals. Here, we determined the differentiation effects of novel analogs of 1α,25-dihydroxyvitamin D₂ (1,25D2), ...
Primary microRNA (pri-miRNA) mimics are important mediators of effective gene silencing and are well suited for sustained therapeutic applications. Pri-miRNA mimics are processed in the endogenous miRNA biogenesis pathway, where elements of the secondary RNA structure are crucial for efficient miRNA production. Cleavage of the pri-miRNA to a precursor miRNA (pre-miRNA) by Drosha-DGCR8 typically...
Canonical primary microRNA transcripts (pri-miRNAs) are characterized by a ∼30 bp hairpin flanked by single-stranded regions. These pri-miRNAs are recognized and cleaved by the Microprocessor complex consisting of the Drosha nuclease and its obligate RNA-binding partner DGCR8. It is not well understood how the Microprocessor specifically recognizes pri-miRNA substrates. Here, we show that in ad...
The cha nges in chemical structure occu ring in pol y (vinyl chloride) as a res ul t of heati ng ina vacu um in t he range 100° to 400° C were studied using infrared spectropho to metry. The pri ncipa l changes occ urri ng in t he residue during p yrolysis in a vacuum were the format ion of unsaturated s tructures a nd a change from an al iphatic spectrum to one showing aromatic absorption. The...
Article history: Received 15 May 2016 Received in revised form 1 September 2016 Accepted 27 December 2016 Available online xxxx The goal of this study was to explore the relationships between the photochemical reflectance index (PRI) at the leaf level and pigment pools, focusing on the constitutive role of pigments in influencing PRI over seasonal or ontogenetic time frames. The purpose was to ...
This paper presents a new feature set for the problem of recognizing pulse repetition interval (PRI) modulation patterns. The recognition is based upon the features extracted from the multiresolution decomposition of different types of PRI modulated sequences. Special emphasis is placed on the recognition of jittered and stagger type PRI sequences due to the fact that these types of PRI sequenc...
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