OBJECTIVE To assess whether women with a history of preterm birth, independent on the presence of prelabour rupture of the membranes (PROM) and growth deviation of the newborn, are more likely to develop preeclampsia with preterm or preterm birth in a subsequent pregnancy. METHODS We conducted a population-based cohort study, based on Medical Birth Registry of Norway between 1967 and 2012, in...

Introduction Preterm birth is defined as delivery before 37 completed weeks (WHO). The issue of preterm birth is still a major health problem in the world; 75% of neonatal mortalities are due to prematurity.(1,3) A variety of morbidities are significantly increased in preterm neonates who survive. Morbidity in multiple organs such as respiratory tract, cardiovascular, GI, metabolic, neurologica...

Background: The purpose of this study was to evaluate the effect of prophylactic vaginal progesterone in decreasing preterm birth rate and neonatal complications in a high-risk population. Materials and Methods: A randomized, double-blind, placebo- controlled study included 100 high-risk singleton pregnancies( prior preterm birth,short cervix,uterine malformations and large intramural uterine m...

BACKGROUND Folic acid-containing multivitamins have been associated with a reduced risk of preterm birth. We examined whether periconceptional use of folic acid alone reduced this risk. METHODS Data were derived from a large population-based cohort study conducted in China to evaluate the prevention of neural tube defects with folic acid supplementation. The sample comprised 207 936 singleton...

Preterm birth is the most important cause of neonatal mortality and morbidity worldwide. In this review, we review potential risk factors associated with preterm birth and the subsequent management to prevent preterm birth in low and high risk women with a singleton or multiple pregnancy. A history of preterm birth is considered the most important risk factor for preterm birth in subsequent pre...

BACKGROUND Ascending infection from the colonized vagina to the normally sterile intrauterine cavity is a well-documented cause of preterm birth. The primary physical barrier to microbial ascension is the cervical canal, which is filled with a dense and protective mucus plug. Despite its central role in separating the vaginal from the intrauterine tract, the barrier properties of cervical mucus...

OBJECTIVE To investigate time trends in preterm birth in Europe by multiplicity, gestational age, and onset of delivery. DESIGN Analysis of aggregate data from routine sources. SETTING Nineteen European countries. POPULATION Live births in 1996, 2000, 2004, and 2008. METHODS Annual risk ratios of preterm birth in each country were estimated with year as a continuous variable for all bir...

BACKGROUND Preterm birth is an unresolved global health issue. The etiologies of preterm birth are complex and multifactorial. To examine risk factors related to preterm birth, a matched case-control study was conducted in a hospital in Beijing, China where little data on preterm birth have been published in the scientific literature. METHODS A 1:1 matched case-control study was conducted in ...

OBJECTIVES Arab Americans have a lower risk for preterm birth than white Americans. We assessed factors that may contribute to the association between ethnicity and preterm birth risk in Michigan, the state with the largest concentration of Arab Americans in the United States. Factors assessed as potential contributors to the ethnicity/preterm birth risk association were maternal age, parity, e...

Worldwide, preterm birth annually affects more than 15 million infants. Despite increasing knowledge of the risk factors and mechanisms associated with preterm labor, the preterm birth rate has risen in most industrialized countries. The ability to identify women at high risk for spontaneous preterm birth is crucial yet remains difficult. The aim of the present study was to assess the value of ...