PURPOSE Sophisticated small animal irradiators, incorporating cone-beam-CT image-guidance, have recently been developed which enable exploration of the efficacy of advanced radiation treatments in the preclinical setting. Microstereotactic-body-radiation-therapy (microSBRT) is one technique of interest, utilizing field sizes in the range of 1-15 mm. Verification of the accuracy of microSBRT tre...

Objective: Radiosensitisation caused by titanium dioxide nanoparticles (TiO2-NPs) is investigated using phantoms (PRESAGE® dosimeters) and in vitro using two types of cell lines, cultured human keratinocyte (HaCaT) and prostate cancer (DU145) cells. Methods: Anatase TiO2-NPs were synthesised, characterised and functionalised to allow dispersion in culture-medium for in vitro studies and halocar...

Clicker technology is one of the most widely adopted communication systems in college classroom environments. Previous literature reviews on clicker technology have identified and thoroughly documented the advantages, disadvantages, and implications of the use of this technology; the current review is intended to synthesize those earlier findings and recast them in terms of the interrelationshi...

A case of idiopathic acquired sideroblastic anaemia transforming to acute myelofibrosis is reported. The appearance of atypical megakaryocytic proliferation in idiopathic acquired sideroblastic anaemia may presage the development of an acute myelofibrotic phase of this usually chronic disease.

This study investigates a reusable PRESAGE® 3D dosimeter (Presage-RU), which would improve cost-effectiveness and facilitate wider implementation of comprehensive, high resolution 3D dosimetry. Small (1x1x4.5 cm) and large (8 cm diameter, 4.5 cm length) sample dosimeters were irradiated multiple times to characterize dose response (i.e. radiation-induced change in optical density (∆OD)), optica...

Both polymer gels and PRESAGE radiochromic solid dosimeter, in conjunction with optical CT scanning system, have been employed to measure 3-D dose distribution. The 3-D dose maps obtained from these systems can provide a useful tool for dose verification on complex treatments such as IMRT, radiosurgery, and RapidArc. These complex treatments present high dose gradient regions in the boundaries ...

Stereotactic radiosurgery has become a widely used technique to treat solid tumors and secondary metastases of the brain. Multiple targets can be simultaneously treated with a single isocenter in order to reduce the set-up time to improve patient comfort and workflow. In this study, a 5-arc multifocal RapidArc treatment was delivered to multiple PRESAGE® dosimeters in order to explore the repea...