BACKGROUND Hormone receptor status is an important prognostic and therapeutic tool in breast cancer. The objectives of our study were to create a database of breast cancer patients in Central Kerala between January 2010 and December 2012 and analyze the proportions of estrogen receptor and progesterone receptor positivity in premenopausal and postmenopausal women with breast cancer. METHODS E...

I read with great interest the article by Verma et al. [1], in which they reported detailed safety analysis in hormone receptor-positive/HER2-negative advanced metastatic breast cancer receiving palbociclib in combination with fulvestrant (PALOMA-3). They found that treatment with palbociclib in combination with fulvestrant was generally safe and well tolerated in patients with hormone receptor...

OBJECTIVE Women with type 2 diabetes appear to lose the protection against cardiovascular disease afforded by estrogens. We examined the effects of menopausal status on postprandial clearance of dietary fat in healthy and diabetic women. RESEARCH DESIGN AND METHODS Fasting subjects (premenopausal and postmenopausal control subjects, premenopausal and postmenopausal diabetic women, all n = 8) ...

BACKGROUND Data on intake of specific carotenoids and breast cancer risk are limited. Furthermore, studies of vitamins A, C, and E in relation to breast cancer risk are inconclusive. We have conducted a large, prospective study to evaluate long-term intakes of these nutrients and breast cancer risk. METHODS We examined, by use of multivariate analysis, associations between intakes of specific...

There is no agreement in defining osteoporosis in premenopausal women and diagnosis must be done carefully and not based on densitometric parameters. One must take into account the presence of other risk factors and history of fragility fractures, diseases or drugs that cause bone loss. Over 50% of premenopausal women with osteoporosis will have a secondary cause, with the remainder diagnosed w...

U mladých, premenopauzálnych žien v súčasnosti neexistujú jednoznačné odporúčania diagnostiky a liečby osteoporózy. Nízka hodnota kostnej hustoty u nie je asociovaná s rovnakým rizikom fraktúry ako postmenopauzálnych žien, preto nich možné diagnostickom procese využiť iba denzitometrické vyšetrenie. Väčšina prípadov premenopauzálnej osteoporózy spôsobená chronick...

OBJECTIVES The purpose of this study was to investigate whether a harmful cardiovascular risk profile accelerates menopause. BACKGROUND Women with an early menopause are at an increased risk of cardiovascular disease. Although increased cardiovascular risk has been proposed as consequence of menopause, the alternative hypothesis, that increased premenopausal cardiovascular risk promotes early...

Adjuvant endocrine therapy is an integral component of care for endocrine-dependent breast cancer. The aim of this type of therapy is to counteract the production and the action of estrogens. The ovary is the primary site of estrogen production in premenopausal women, whereas, in postmenopausal women, the main source of estrogens is adipose tissue. Therefore, ovarian function suppression is an ...

The purpose of the study was to assess physiologic endometrial 18F-FDG uptake during the 4 phases of the menstrual cycle and to differentiate between physiologic and malignant endometrial uptake. Methods: Endometrial 18F-FDG uptake, expressed as standardized uptake value (SUV), was measured on PET/CT images of 285 consecutive female patients, of whom 246 (112 premenopausal and 134 postmenopausa...

Data from the National Health Interview Survey, 2015. Among those aged 40-59, perimenopausal women (56.0%) were more likely than postmenopausal (40.5%) and premenopausal (32.5%) women to sleep less than 7 hours, on average, in a 24-hour period. Postmenopausal women aged 40-59 were more likely than premenopausal women aged 40-59 to have trouble falling asleep (27.1% compared with 16.8%, respecti...