The hormonal status of women with a diagnosis STUMP, removal one ovary and without surgery were prospectively studied. study the background revealed ovarian insufficiency syndrome in after surgical treatment. Our studies carried out period from 1 month to 3 months, 4 6 months 7 12 operation. We investigated changes level main informative hormones FSH, E2, LH, AMH, since other hormones, such as ...

Premature ovarian insufficiency (POI) is a typical disorder of amenorrhea lasting for a minimum of 4 months. The typical characteristics comprised of declined estrogen and raised serum concentrations of follicle-stimulating hormone (FSH) in women <40-year-old, primarily originating from iatrogenic factors, karyotypic abnormalities, and genetic factors. However, the etiology of POI remains unkno...

The use of triptolide (TP) is limited by its poor water solubility and severe toxicity. In this study, we developed an active drug delivery system (TP-loaded nanoparticles) that could help improve the water solubility of TP and decrease its toxicity. Then, we investigated whether TP-loaded nanoparticles could be used to establish a novel premature ovarian insufficiency mouse model. The mice tre...

Primary ovarian insufficiency is a condition that represents impaired ovarian function on a continuum with intermittent ovulation. This condition commonly leads to premature menopause, defined as cessation of ovulation prior to the age of 40 years. Because there are potential immediate and long-term consequences of hypoestrogenism, a timely diagnosis is invaluable. This comprehensive review wil...

Abstract Background Premature ovarian insufficiency (POI) is characterized by impairment of function on a continuum before the age 40 years. POI affected multiple factors. Considering new insights from recent gut microbiome studies, this study aimed to investigate relationship between microbial community structure and POI. Methods Subjects were recruited at Shenzhen Maternity &amp; Child Health...