A mother and daughter are described with premature menopause and deletion of the X chromosome at q28. Structural anomalies of the X chromosome and ovarian failure are well known.' Secondary amenorrhoea, recognised as premature menopause and involving an X chromosomal deletion, has only been described on two occasions, the breakpoints being at q252 and q26.3 We describe familial inheritance of a...

Owing to the improved effectiveness of the treatment protocols for oncological disease, in the last few years we have seen an increase in the number of women in iatrogenic menopause secondary to integrated oncological treatments or surgical, pharmacological or radiological therapies. Particularly if it is premature, menopause in these subjects, who are already strongly debilitated by the primar...

SIGNIFICANCE There are 2.2 million breast cancer survivors, and approximately 25%-30% of newly diagnosed women each year are <50 years of age. Adjuvant therapy has prolonged survival, but the quality of that survival is influenced by persistent and late effects of therapy. Knowledge of treatment outcomes will assist in the design of interventions to prevent or manage persistent and late effects...

BACKGROUND A regular menstrual cycle is an important indicator of a healthy reproductive system. Previous studies reported obesity, stress, and smoking as the factors that are associated with irregular menstruation and early menopause. However, the integrative effects of these modifiable risk factors have not been fully understood. This study aimed to investigate the modifiable risk factors of ...