Toxemia of pregnancy is a symptom complex which occurs during pregnancy and consists of three essential manifestations; hypertension, proteinuria and edema. Although extensive attempts have been made to explain the genesis of toxemia, none is satisfactory to date. Recently it has been assumed that a humoral substance is liberated and changes the metabolism of the gravids. Hunter and Howard1) re...

Pregnancy disease (pregnancy toxemia, twin lamb disease, lambing sickness, lambing paralysis or lambing ketosis) typically affects ewes during the last 2 to 4 weeks of pregnancy and is a common cause of ewe and lamb loss in Michigan flocks. Overconditioned or thin ewes, usually pregnant with multiple fetuses, are most commonly affected and clinical cases are generally limited to older ewes duri...

In an attempt to determine the cause and nature of the toxemias of pregnancy, the records of patients who were admitted to the New Haven Hospital with the diagnosis of toxemia of pregnancy or who had renal or vascular disease that had apparently arisen during pregnancy have been reviewed. Altogether 309 of the first class and 11 of the second were found with records complete enough to warrant a...

Toxic affections associated with pregnancy have been reported in several species of animals, notably the sheep (2)and guinea pig (3); it is also common knowledge among breeders that overfat animals of all kinds are apt to die during gestation or parturition, but the exact nature and pathogenesis of these disorders is not known. A highly fatal affection associated with pregnancy also occurs in t...

The clinical manifestations and pathology of a disorder associated with pregnancy in the rabbit have been described. The disorder bears a close analogy to toxemia of pregnancy in man and offers an experimental approach to the problems associated with that condition. The evidence at hand indicates that the disorder is of endogenous origin and arises from a disturbance of functions concerned in r...

The vascular and renal disorders of the last trimester of pregnancy are classified by the University Obstetrical Service in the following groups: specific toxemia, pre-existing essential hypertension, pre-existing glomerulonephritis and specific toxemia superimposed on pre-existing hypertension or nephritis (1). Specific toxemia is clinically characterized by the rather abrupt appearance of hyp...