Cervical cancer remains the fourth most common cause of cancer-related deaths in women worldwide, and human papillomavirus infection represents the most important risk factor for the development of cervical cancer. Minichromosome maintenance protein-2 has been previously identified by DNA microarray and transcriptional profiling as genes that is overexpressed in cervical carcinomas. 183 cases w...

In many tumors, the switch from precancerous lesions to malignancy critically relies on expression of the matrix-metalloprotease MMP-9, which is predominantly provided by infiltrating inflammatory cells. Our study defines a novel molecular cascade, how human neoplastic cells instruct tumor-associated myeloid cells to produce MMP-9. In biopsies of human papillomavirus-associated precancerous cer...

Cervical cancer is a significant gynaecological cancer in women, and is preventable by regular screening using the Papanicolaou technique. Screening identifies precancerous lesions that convey a risk of invasive cancer. These lesions can be removed which reduces the population incidence of cervical cancer (primary prevention). Screening can also detect early asymptomatic invasive cancer and thu...

The Polish Society of Colposcopy and Cervical Pathophysiology (PTKiPSM) together with the Gynecologists Obstetricians (PTGiP) issued a final summary interim guidelines for secondary cervical cancer prevention during SARS-CoV-2 pandemic based on analysis latest directional publications authors’ own experiences. aim is to facilitate implementation most effective possible screening precancerous le...

Human papillomavirus (HPV) is a sexually transmitted pathogen that plays an important role in the pathogenesis of precancerous cervical lesions and cervical cancer.1 The prevalence of HPV types in Hong Kong differs from that in Sichuan, China. Cross-border travel and marriage between people in Hong Kong and Guangzhou have increased greatly, as has the potential for disease transmission. Integra...

UNLABELLED According to the Public Health Institute of the Federation of Bosnia and Herzegovina there were 132 newly diagnosed patients with cervical cancer in 2008. AIM The aim of this article is to present the incidence of precancerous changes on the cervix and cervical cancer as well as the incidence of the use of conization as the type of treatment for cervical patients. METHODS The num...

Studies have suggested that p16(ink4a) may be a surrogate biomarker for the diagnosis of cervical cancer; however, the function of p16(ink4a) in human cervical cancer cells remains largely unknown. Therefore, in this study, we aimed to investigate the role of p16(ink4a) in human cervical cancer cells. Immunocytochemistry was used to examine invasive squamous cell carcinoma and its precancerous ...

BACKGROUND The cytological interpretation of ASC-US represents a category of morphologic uncertainty. For patients with this result, other tests are necessary in order to determine the risk for cervical lesions. MATERIALS AND METHODS 198 patients with ASC-US cytology have been analyzed between 2008 and 2013. All the patients included in the study have subsequently had a high oncogenic HPV tes...