OBJECTIVES Previous studies have found that Panax quinquefolius saponins (PQS) combined with dual antiplatelet therapy (DAPT) of aspirin and clopidogrel enhances antithrombotic effects while reducing gastric mucosal injury induced by DAPT. We investigated the effects of the combined drug therapy (PQS+DAPT) through the COX/PG pathways. METHODS Acute myocardial infarction (AMI) was induced in W...

Pseudomonas aeruginosa is an opportunistic pathogen that causes serious infections in immunocompromised patients and those with cystic fibrosis (CF). This gram-negative bacterium uses multiple cell-to-cell signals to control numerous cellular functions and virulence. One of these signals is 2-heptyl-3-hydroxy-4-quinolone, which is referred to as the Pseudomonas quinolone signal (PQS). This sign...

Many bacterial species, including the human pathogen Pseudomonas aeruginosa, employ a mechanism of intercellular communication known as quorum sensing (QS), which is mediated by signalling molecules termed autoinducers. The Pseudomonas Quinolone Signal (PQS) and 2-Heptyl-3H-4-Quinolone (HHQ) are autoinducers in P. aeruginosa, and they are considered important factors in the progress of infectio...

Structural data as collated in the Protein Data Bank (PDB) have been widely applied in the study and prediction of protein-protein interactions. However, since the basic PDB Entries contain only the contents of the asymmetric unit rather than the biological unit, some key interactions may be missed by analysing only the PDB Entry. A total of 69,054 SCOP (Structural Classification of Proteins) d...

Pseudomonas aeruginosa is an opportunistic pathogen that causes both acute and chronic infections in immunocompromised individuals. This gram-negative bacterium produces a battery of virulence factors that allow it to infect and survive in many different hostile environments. The control of many of these virulence factors falls under the influence of one of three P. aeruginosa cell-to-cell sign...

Abstract A saturable absorber based on a novel two‐dimensional (2D) material Bi 2 O Se was placed in resonator with an overall longest diameter of 31 mm to achieve efficient operation passively Q‐switched (PQS) Tm:YAP laser for the first time. In PQS mode, 1.62‐W average output power pulse width 1.24 µs and repetition frequency 112.1 kHz achieved at pump 22.2 W, corresponding peak 11.66 W. As 2...

Clustered regularly interspaced palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins, particularly Cas9, have provided unprecedented control on targeting editing specific DNA sequences. If the target sequences are prone to folding into noncanonical secondary structures, such as G-quadruplex (GQ), conformational states activity of CRISPR–Cas9 complex may be influenced, but impact ha...

The perceptual measures are often used to assess distortions in image compression. In this article different images were evaluated using the Picture Quality Scale (PQS) measure with neural network. On the basis of original and compressed images the local distortions in the compressed image are calculated. Then five factors {F1, F2, F3, F4, F5}, which represent these distortions are computed, an...

Pseudomonas aeruginosa uses a hierarchical quorum sensing (QS) network consisting of las, pqs and rhl regulatory elements to coordinate the expression of bacterial virulence genes. However, clinical isolates frequently contain loss-of-function mutations in the central las system. This motivated us to search for a mechanism that may functionally substitute las. Here we report identification of a...

In this paper we present a new server monitoring method based on a new and powerful approach to dynamic data analysis: Process Query Systems (PQS). PQS enables userspace monitoring of servers and, by using advanced behavioral models, makes accurate and fast decisions regarding server and service state. Data to support state estimation come from multiple sensor feeds located within a server netw...