BACKGROUND The purpose of this study was to examine the effect of proton pump inhibitors (PPI) on the antiplatelet activity of clopidogrel in a consecutive series of Chinese patients after they had received coronary stents. METHODS A sample of 51 consecutive Chinese patients treated with coronary stents and taking PPI and clopidogrel for more than 30 days were enrolled in this study. Mean val...

Deficits in prepulse inhibition (PPI) are a biological marker for schizophrenia. To unravel the mechanisms that control PPI, we performed quantitative trait loci (QTL) analysis on 1,010 F2 mice derived by crossing C57BL/6 (B6) animals that show high PPI with C3H/He (C3) animals that show low PPI. We detected six major loci for PPI, six for the acoustic startle response, and four for latency to ...

BACKGROUND Aspirin, when used with concurrent anticoagulation, increases the risk of gastrointestinal bleeding (GIB). Therefore, multisociety guidelines recommend prophylactic proton-pump inhibitors (PPIs) for patients receiving aspirin and anticoagulation. We aimed to determine rates and predictors of adherence to these recommendations. METHODS All adult inpatients discharged from the hospit...

BACKGROUND & AIMS Use of proton pump inhibitors (PPIs) could predispose individuals to small intestinal bacterial overgrowth (SIBO) by altering the intraluminal environment and bacterial flora. There is controversy regarding the risk of SIBO among PPI users because of conflicting results from prior studies. A systematic review and meta-analysis were performed to evaluate the association between...

BACKGROUND Duodenal ulcer (DU) bleeding has a 7 - 13% mortality rate and bleeding often recurs. Prevention of recurrence is, therefore, an important goal. Eradication of Helicobacter pylori or maintenance treatment with a proton pump inhibitor (PPI) may reduce recurrent DU bleeding. Economic comparison of these options is sparse. METHODS After the control of index bleeding with endotherapy an...

background helicobacter pylori diagnostic tests can be affected by different interventional factors. we studied the effects of smoking, proton pump inhibitors (ppis) and antibiotic administration on results of the bacterial culture, and its diagnosis tests due to polymerase chain reaction (pcr) and rapid urease test (rut) methods. objectives this study was aimed to investigate the undesirable e...

The relationship between PPI and CPI is one of the hotspots in study macroeconomics. Taking China as an example, paper tests dynamic causality during period 2000:M1-2019:M12. In view structural mutations time series variables, bootstrap rolling-window test applied to restudy causal relationship. As a result, it exists bidirectional transmission mechanism PPI, both positive reverse PPI. addition...

BACKGROUND/AIMS To evaluate the value of a 2-week high dose proton pump inhibitor (PPI) treatment on patients with overlapping non-erosive gastroesophageal reflux disease (NERD) and functional dyspepsia (FD). METHODS Sixty overlapping NERD and FD patients with symptom onset > 3 months prior underwent 24-hour esophageal pH monitoring studies. All patients received rabeprazole 20 mg b.i.d. for ...

The 8255A programmable peripheral interface PPI) implements a general-purpose I/O interface to connect peripheral equipment to a microcomputer system bus. The core’s functional configuration is designed by VHDL code and designed input signal (Test bench) for PPI 8255, which is generated by VHDL code. Simulated result is verified for one 8bit Peripheral Ports Ports A, three programming modes for...

Dyspepsia is common in the community, and the condition represents a considerable burden to the health service. Individuals over the age of 50 to 55 years consulting with new-onset dyspepsia and those with alarming features, such as dysphagia and weight loss, require urgent endoscopy to exclude gastro-esophageal malignancy. For younger individuals without alarm features prompt endoscopy and "te...