Peroxisome proliferator–activated receptor ; (PPAR;) is known to be expressed in several cancers, and the treatment of these cancer cells with PPAR; ligands often induces cell differentiation and apoptosis. Recently, the chemopreventive potential of PPAR; ligands on colon carcinogenesis was reported, although the effect of PPAR; on colon carcinogenesis and the mechanism of the effect remain con...

Peroxisome proliferator-activated receptors (PPARs), members of the superfamily of nuclear steroid hormone receptors, have traditionally been studied for their role in lipid, glucose, and energy homeostasis. Recent evidence suggests that pharmacological activation of PPAR and PPAR , and inhibition of PPAR , may prevent cancer. PPAR agonists induce differentiation, inhibit the growth of establis...

Kaempferide (Ka, 3,5,7-trihydroxy-4?-methoxyflavone), an active ingredient of Tagetes erecta L., has been demonstrated to possess many pharmacological effects, including antioxidant, anti-inflammation, anticancer and antihypertension in previous study. However, there is no evidence Ka on metabolic disorder former studies. This study investigated the effects glycolipid metabolism explored underl...

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is being studied intensively for its role in carcinogenesis and in mediating the effects of prostate cancer treatment and prevention drugs. Prostate cancers express abundant and higher constitutive levels of PPAR-gamma than do normal prostate cells and are growth inhibited by ligand activation of PPAR-gamma. However, little is known ...

Objectives—Peroxisome proliferator-activated receptor / (PPAR / ) is a nuclear receptor found in platelets. PPAR / agonists acutely inhibit platelet function within a few minutes of addition. As platelets are anucleated, the effects of PPAR / agonists on platelets must be nongenomic. Currently, the particular role of PPAR / receptors and their intracellular signaling pathways in platelets are n...

Activation of the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPAR-γ) has been shown to be immunoregulatory in autoimmune diseases by inhibiting production of a number of inflammatory mediators. We investigated whether PPAR-γ gene deletion in hematopoietic cells would alter disease pathogenesis in the antiglomerular basement membrane (anti-GBM) mouse model. PPAR-γ...

Natural and synthetic agonists of the peroxisome proliferatoractivated receptor (PPAR ) regulate adipocyte differentiation, glucose homeostasis, and inflammatory responses. Although effects on adipogenesis and glucose metabolism are genetically linked to PPAR , the PPAR dependence of antiinflammatory responses of these substances is less clear. Here, we have used a combination of mRNA expressio...

Background—The peroxisome proliferator–activated receptor(PPAR ) plays important roles in lipid metabolism, inflammation, and atherosclerosis. PPAR ligands have been shown to reduce cardiovascular events in high-risk subjects. PPAR expression by arterial cells, including macrophages, may exert local antiatherogenic effects independent of plasma lipid changes. Methods and Results—To examine the ...

Peroxisome proliferator-activated receptors (PPARs) are transcription factors that belong to the nuclear hormone receptor superfamily. PPAR and PPAR ligands have been demonstrated to exert anti-inflammatory activities in macrophages by repressing the activities of several transcription factors. PPAR is expressed in T lymphocytes and may play a role in cytokine production, cellular proliferation...

Peroxisome proliferator-activated receptor (PPAR) is an important signaling molecule in cells of mesenchymal origin, inducing differentiation and regulating cell proliferation in several cell types such as vascular smooth muscle cells. Leiomyomas arise from smooth muscle cells of the uterine myometrium with an incidence rate as high as 70% in women of reproductive age. PPAR signaling has not be...