SUMMARY Roller compacted hydrophilic polymer combinations were used to formulate verapamil hydrochloride (HCl) extended release hydrophilic matrix tablets. The effect of roller compaction (RC) parameters on the properties of blended polymers, tablets and drug release were investigated. RC granulation improved the powder properties without affecting the pharmacotechnical properties or the drug r...

Apart from a great variety of shaping possibilities powder metallurgical techniques offer the integration of foreign elements for static and variable data storage or to embed elements with sensory features in structural parts. The integration of foreign elements as single parts arranged in matrices or traces of foreign powders allows for storing information like brand, serial numbers or other c...

We have investigated experimentally the influence of a magnetic interaction between the grains on the compaction dynamics of a granular pile submitted to a series of taps. The granular material used to perform this study is a mixture of metallic and glass grains. The packing is immersed in homogeneous external magnetic field. The magnetic field induces an interaction between the metallic grains...

EFFECTIVE COMPUTER SIMULATIONS of metal powder compaction and sintering are at the top of the powder metallurgy industry’s wish list. There is much anticipated advantage to such efforts, yet there are problems that will inhibit widespread implementation. Press-sinter powder metallurgy computer simulations currently focus on the use of minimal input data to help with process setup. Although the ...

The aim of this project is to develop methods for scaling up roller compaction process from lab scale to pilot scale, to determine the effect of processing parameters of roller compactors at both lab scale (instrumented roller compactor at University of Birmingham, micro-pactor at Pfizer) and pilot scale (mini-pactor from Gerteis) on the attributes of dry-granulated formulations, including the ...

Large numbers of cohesive powders are compacted using a roll press. The principle of compaction is that particulate materials become a compact when they are subjected to high pressure. Experimental work was carried out on pharmaceutical powders [1] to determine the influence of operating parameters on the roll process compaction. Theses parameters are determined for a given powder and must be m...

The aim of this study was to evaluate the compaction property of several pharmaceutical materials by measuring the die wall pressure. The profile of die wall force during tabletting process was measured with the compaction process analyzer (TabAll). Several compaction parameters such as maximum die wall pressure (MDP), residual die wall pressure (RDP) and pressure transmission ratio (PTR) from ...