نتایج جستجو برای: potassium polymorphism

تعداد نتایج: 184444  

Journal: :iranian journal of pharmaceutical research 0
mohsen imenshahidi pharmacy faculty, mashhad university of medical sciences, mashhad, iran. farzin hadizadeh pharmacy faculty, mashhad university of medical sciences, mashhad, iran. biotechnology research center, mashhad university of medical sciences, mashhad, iran. asieh firoozeh-moghadam pharmacy faculty, mashhad university of medical sciences, mashhad, iran. mahmoud seifi pharmacy faculty, mashhad university of medical sciences, mashhad, iran. atefeh shirinbak pharmacy faculty, mashhad university of medical sciences, mashhad, iran. mohammad bagher gharedaghi pharmacy faculty, mashhad university of medical sciences, mashhad, iran.

atp-sensitive potassium (katp) channel openers have a relaxation effect due to the lower cellular membrane potential and inhibit calcium influx. there has been considerable interest in exploring katp channel openers in the treatment of various diseases such as cardiovascular, cerebrovascular, and urinary system disease and premature labor. the purpose of this study was to synthesize 3,3,6,6-tet...

Journal: :Genetics and molecular research : GMR 2014
M D Bazzi F A Nasr M S Alanazi A Alamri A A Turjoman A S Moustafa A A Alfadda A A K Pathan N R Parine

Recent genome wide association studies identified many loci in several genes that have been consistently associated with type 2 diabetes mellitus in various ethnic populations. Among the genes that were most strongly associated with diabetes were fat mass- and obesity-associated, melanocortin 4 receptor, solute carrier family 30 member 8 (SLC30A8), and a member of the potassium voltage-gated ch...

2013
Jan Palacký Michaela Vorlíčková Iva Kejnovská Peter Mojzeš

DNA concentration has been recently suggested to be the reason why different arrangements are revealed for K(+)-stabilized human telomere quadruplexes by experimental methods requiring DNA concentrations differing by orders of magnitude. As Raman spectroscopy can be applied to DNA samples ranging from those accessible by absorption and CD spectroscopies up to extremely concentrated solutions, g...

2014
Bertha Muñoz-Hernández Gabriel Palma-Cortés Carlos Cabello-Gutiérrez María Angeles Martínez-Rivera

BACKGROUND Coccidioides spp. is the ethiological agent of coccidioidomycosis, an infection that can be fatal. Its diagnosis is complicated, due to that it shares clinical and histopathological characteristics with other pulmonary mycoses. Coccidioides spp. is a dimorphic fungus and, in its saprobic phase, grows as a mycelium, forming a large amount of arthroconidia. In susceptible persons, arth...

Journal: :Genetics and molecular research : GMR 2014
H G Han H S Wang Z Yin H Jiang M Fang J Han

KCNE1, a membrane protein that spans the membrane once is responsible for modulating potassium channel functions and plays an important role in the etiology of arrhythmia. Emerging evidence indicates that a common polymorphism (112G>A; rs1805127 G>A) in the KCNE1 gene contributes to atrial fibrillation (AF) risk; however, these studies showed inconclusive results. In this meta-analysis, we deri...

Journal: :Circulation. Cardiovascular genetics 2012
Stefan Kääb Dana C Crawford Moritz F Sinner Elijah R Behr Prince J Kannankeril Arthur A M Wilde Connie R Bezzina Eric Schulze-Bahr Pascale Guicheney Nanette H Bishopric Robert J Myerburg Jean-Jacques Schott Arne Pfeufer Britt-Maria Beckmann Eimo Martens Taifang Zhang Birgit Stallmeyer Sven Zumhagen Isabelle Denjoy Abdennasser Bardai Isabelle C Van Gelder Yalda Jamshidi Chrysoula Dalageorgou Vanessa Marshall Steve Jeffery Saad Shakir A John Camm Gerhard Steinbeck Siegfried Perz Peter Lichtner Thomas Meitinger Annette Peters H-Erich Wichmann Christiana Ingram Yuki Bradford Shannon Carter Kris Norris Marylyn D Ritchie Alfred L George Dan M Roden

BACKGROUND Drug-induced long-QT syndrome (diLQTS) is an adverse drug effect that has an important impact on drug use, development, and regulation. We tested the hypothesis that common variants in key genes controlling cardiac electric properties modify the risk of diLQTS. METHODS AND RESULTS In a case-control setting, we included 176 patients of European descent from North America and Europe ...

2017
Yuan-Yuan Han Li-Jie Wang Liang Zhang Wen-Wen Zhang Ke-Tao Ma Li Li Jun-Qiang Si

The aim of the present study was to examine whether single-nucleotide polymorphisms (SNPs) of β1 subunit of large-conductance Ca2+-activated K+ channel (KCNMB1) and inwardly rectifying K+ channel, subfamily J, member-11 (KCNJ11) are associated with essential hypertension (EH) in Xinjiang Kazak Chinese patients. A polymerase chain reaction-restriction fragment length polymorphism technique was a...

2013
Hui-min Chu Ming-jun Feng Yi-gang Li Yi-xin Zhang Ji-fang Ma Bin He Yi-bo Yu Jing Liu Xiao-min Chen

BACKGROUND Recent studies suggest that mutation of the slow delayed rectifier potassium channel (IKs) contributes to familial atrial fibrillation (FAF). In the current study, we identified common genetic variants of KCNQ1 and explored the potential association between KCNQ1 polymorphism with lone AF (LAF). METHODS Clinical data and blood samples were collected from 190 Han Chinese patients wi...

Journal: Desert 2009
Gh. Rahimi H. Mehrabani Yeganeh H. Moradi Shahrbabak M. Moradi Shahrbabak

Abstract The whole blood potassium concentration has shown the bimodal distribution in sheep, which has been classified into LK and HK types; HK allele is recessive to LK with a single gene inheritance. This polymorphism showed different behavior in different environment, which could be due to adaptation process. This research was conducted on the Zel and kermani breed research station, which...

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