Background. Postoperative nausea and vomiting (PONV) is a significant complication after laparoscopic surgeries. Ondansetron and dexamethasone are most commonly used drugs for PONV prophylaxis. Comparisons of these two drugs have not been systematically reviewed till date.Methods. PubMed, PubMed Central, and CENTRAL databases were searched with the following words: “dexamethasone,” “ondansetron...

Postoperative nausea and vomiting (PONV) are unpleasant experiences. However, there is no drug that is completely effective in preventing PONV. Whereas cost effectiveness analyses rely on specific health outcomes (e.g., years of life saved), cost-benefit analyses assess the cost and benefit of medical therapy in terms of dollars. We hypothesized that patients were willing to pay for a hypotheti...

Background: The effects of different opioids on postoperative nausea and vomiting (PONV) and pain have not been conclusively determined. The aim of this study was to compare the effects of fentanyl, remifentanil or fentanyl plus morphine on the incidence of PONV and pain in women subjected to cesarean section under general anesthesia. Methods: The study was a randomized clinical trial r...

BACKGROUND Nausea and vomiting are common chief postoperative complaints. The clinical literature indicates that postoperative nausea and vomiting (PONV) is common after orthopedic surgery. This study examines the clinical therapeutic efficacy of Ondansetron injected intravenously before the end of shoulder arthroscopy as antiemetic prophylaxis to help reduce the incidence of PONV. METHODS Pa...

It is well appreciated that a number of things (e.g., various insults, chemotherapeutic agents, radiation) may lead to the release of serotonin from the enterochromaffin of the gastrointestinal tract. Released serotonin may then bind to certain 5-HT3 receptors and promote nausea/vomiting. 5-HT3 receptor antagonists may ameliorate nausea/vomiting in a number of circumstances and have been utiliz...

Purpose: Prevention of postoperative nausea and vomiting (PONV) for orthognathic surgery is very important because of intermaxillary fixation. The aim of this study is to compare the eff ic iency of dexamethasone and metoclopramide in prevention of PONV. Materials and Methods: 22 patients age 15-50, ASA I-II, undergoing orthognathic surgery were randomly allocated in two groups. Group D n=11 –u...

Side effects of surgical procedures are frequent at postoperative, pain, nausea and vomiting are common. Although there is a major concern with prevention of pain, vomiting at postoperative occurs in about 30% of patients.(1) Postoperative nausea and vomiting (PONV) are defined as development of episodes of nausea and emesis after a surgical act and before hospital discharge. Nausea is defined ...

OBJECTIVE To compare the results of Tropisetron, Metoclopramide and placebo on postoperative nausea and vomiting in patients undergoing minilaparotomy cholecystectomy. SETTING Patients operated for minilaparotomy cholecystectomy in two private hospitals in Karachi. SUBJECTS Fifty consecutive patients of all ages and both sex who had simple cholelithiasis and underwent minilaparotomy cholecy...

POSTOPERATIVE NAUSEA AND VOMiting (PONV) frequently complicates recovery from surgery. Before the 1960s, when older inhalational anesthetic agents such as ether and cyclopropane were widely used, the incidence of vomiting was as high as 60%. Better anesthetic techniques, along with a new generation of antiemetics and shorter-acting anesthetic drugs, have reduced the overall incidence of PONV to...