We consider the finite generation-time effect in virus evolution models, introducing differential equations with delay. The suggested approach more adequately describes the evolution in case of growing populations than the popular models of population genetics, especially for the viruses with large number of offspring during one life cycle. Now the mean fitness, as a coefficient for exponential...

Effective population size is fundamental in population genetics and characterizes genetic diversity. To infer past population dynamics from molecular sequence data, coalescent-based models have been developed for Bayesian nonparametric estimation of effective population size over time. Among the most successful is a Gaussian Markov random field (GMRF) model for a single gene locus. Here, we pre...

This document describes the Gold Standard populations of outbred laboratory animals that have been developed at Charles River Laboratories. Using modern techniques of population and molecular genetics, the Gold Standard populations are carefully managed in such a way as to preserve genetic variation and to provide a reliable source of outbred animals for experimental use. The Gold Standard anim...

The increasing availability of large-scale and high-resolution data sets in population genetics is moving the field toward a novel research agenda. Here, we show how this shift toward macrogenetics should generate new perspectives and theories allowing the description, understanding, and prediction of patterns of genetic diversity at broad spatial, temporal, and taxonomic scales.

Despite the widespread study of genetic variation in admixed human populations, such as African-Americans, there has not been an evaluation of the effects of recent admixture on patterns of polymorphism or inferences about population demography. These issues are particularly relevant because estimates of the timing and magnitude of population growth in Africa have differed among previous studie...