Pharmacokinetics and pharmacodynamics are divisions of pharmacology that study the action of the body on the drug and the action of the drug on the body, respectively. They complete dose titration studies aimed to select rational dosage regimens. The classical pharmacokinetic (PK)/pharmacodynamic (PD) studies are experimental. They are usually performed on healthy volunteers or highly selected ...

There has been substantial progress in understanding the production of individual speech sounds. Much less is known about prosodic aspects of speech production. Lexical stress is the prosodic contrast between strong and weak syllables within single words (compare ‘INcense’ with ‘inCENSE’ in English). The ability to achieve stress contrastivity during speech production shows a protracted develop...

A new transmission model of human malaria in a partially immune population with three discrete delays is formulated for variable host and vector populations. These are latent period in the host population, latent period in the vector population and duration of partial immunity. The results of our mathematical analysis indicate that a threshold parameterR0 exists. ForR0 > 1, the expected number ...

This study estimates income effects of health based on observations in China, the largest developing economy in the world. We derive the basic analytical model treating health as a form of human capital in income production. The major findings of this study are: First, China’s experience suggests that health human capital may have played a role in its rapid income growth during the 1990s. Secon...

aim : the aim of this study is to estimate gastric cancer (gc) mortality rate for iranian population, using bayesian approach in order to revise the existing classification which is thought to be a misclassification. background : gastric cancer (gc) is an important cause of mortality among many other types of cancer. data on cancer mortality can be used to guide policy makers in order to setup ...

Food and drink are two of the most basic needs of human beings. However, as society evolved, food and drink became also a strong cultural aspect, being able to describe strong differences among people. Traditional methods used to analyze cross-cultural differences are mainly based on surveys and, for this reason, they are very difficult to represent a significant statistical sample at a global ...