In order to improve the water-solubility of curcumin, the complex between curcumin and hyperbranched poly(amide-ester) was formed by dispering the solid curcumin in hyperbranched poly(amide-ester) aqueous solution. The interaction process was characterized by UV-vis absorption spectroscopy, Fluorescence quenching method, Fourier transformation-infrared spectroscopy, thermogravimetric analysis. ...

Carvedilol is an effective nonselective alpha-1 and beta blocker discovered by Fritz Wiedemann [1] . It is an antihypertensive drug indicated for the treatment of mild to severe congestive heart failure (CHF), angina pectoris, cardiac arrhythmias and myocardial infarction [2] . Water solubility of Carvedilol is a fundamental property that affects the drug absorption after oral administration. M...

low solubility and dissolution rate are the primary challenges in the drug development which substantially impact the oral absorption and bioavailability of drugs. due to the poor water solubility, albendazole (abz) is poorly absorbed from the gastrointestinal tract and shows low oral bioavailability (5%) which is a major disadvantage for the systemic use of abz. to improve the solubility and d...

Supplementary Figure 1. Fullerence has poor solubility in water while the C60S and LC60S nanoparticles can be stably dispersed in water. (a) A typical photograph of fullerence (C60), C60S nanoparticles, and LC60S nanoparticles in deionized water (2 mg ml-1). The C60S and LC60S nanoparticles can be well dispersed in deionized water while fullerene forms aggregates and sinks down at the bottom of...

the treatment of erectile dysfunction (1). It is a selective, potent and reversible competitive inhibitor of the enzyme phosphodiesterase-5 (PDE5), which causes inactivation of cyclic guanosine monophosphate (cGMP) (2). Due to longer duration of its action (approximately 36 hours) and minimum potential to cause vision abnormalities, tadalafil has gained wide clinical acceptance. However, it has...

Introduction: During the last decade, the trend in drug discovery has increased the number of active pharmaceutical ingredients (APIs) that exhibit high lipophilicity and poor water solubility, also associated with poor dissolution characteristics (Vogt et al., 2008). Dissolution rate in the gastrointestinal tract is the rate limiting factor for the absorption of many of these drugs, which ther...

Pyrazolo[3,4-d]pyrimidines are a class of compounds with a good activity against several cancer cell lines. Despite the promising anticancer activity, these molecules showed a poor aqueous solubility. This issue could threat the future development of pyrazolo[3,4-d]pyrimidines as clinical drug candidates. With the aim of improving their solubility profile and consequently their pharmacokinetic ...

The clinical application of dihydroartemisinin (DHA) has been hampered due to its poor water-solubility. To overcome this hurdle, we devised a novel polymer-drug conjugate, multiarm polyethylene glycol-dihydroartemisinin (PEG-DHA), made by linking DHA with multiarm polyethylene glycol. Herein, we investigated PEG-DHA on chemical structure, hydrolysis, solubility, hemolysis, cell cytotoxicity in...

the formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, poor dissolution and poor wetting of these drugs. consequently, the aim of this study was to improve the dissolution of a model poorly water soluble drug, ibuprofen. microparticles containing ibuprofen were produced by spray drying and spray chilling technology in the absence/presence of a hydroph...