نتایج جستجو برای: pon1 activity

تعداد نتایج: 1134962  

Journal: :Clinical chemistry 2004
Christoph Bergmeier Rüdiger Siekmeier Werner Gross

BACKGROUND Paraoxonase (PON1) associated with HDL can be regarded as a cardio- and vasoprotective enzyme. However, because HDL is not a homogeneous fraction, it is important to investigate in which subgroups of HDL active PON1 is located. It would also be useful to determine density profiles of the HDL apolipoproteins (Apo) E and J. METHODS We investigated the density range of HDL (rho = 1.06...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2012
Tomoko Ishizuka Izumi Fujimori Atsuko Nishida Hidetaka Sakurai Yasushi Yoshigae Kaori Nakahara Atsushi Kurihara Toshihiko Ikeda Takashi Izumi

Olmesartan medoxomil (OM) is a prodrug-type angiotensin II type 1 receptor antagonist. The OM-hydrolyzing enzyme responsible for prodrug bioactivation was purified from human plasma through successive column chromatography and was molecularly identified through N-terminal amino acid sequencing, which resulted in a sequence of 20 amino acids identical to that of human paraoxonase 1 (PON1). Two r...

2012
Bharti Mackness Judit Marsillach Robert S. Elkeles Ian F. Godsland Michael D. Feher Michael B. Rubens Marcus D. Flather Steve E. Humphries Jackie Cooper Mike Mackness

OBJECTIVES To determine any association between serum paraoxonase-1 (PON1) activity, protein and coding region genetic polymorphisms and coronary artery calcification (CACS) and to determine factors which modulate serum PON1 in type 2 diabetes (T2DM). METHODS AND RESULTS 589 patients (419 Caucasian, 120 South Asian, 50 other) from the PREDICT Study were investigated. All patients were asympto...

Journal: :The Journal of clinical investigation 2013
Ying Huang Zhiping Wu Meliana Riwanto Shengqiang Gao Bruce S Levison Xiaodong Gu Xiaoming Fu Matthew A Wagner Christian Besler Gary Gerstenecker Renliang Zhang Xin-Min Li Anthony J DiDonato Valentin Gogonea W H Wilson Tang Jonathan D Smith Edward F Plow Paul L Fox Diana M Shih Aldons J Lusis Edward A Fisher Joseph A DiDonato Ulf Landmesser Stanley L Hazen

Myeloperoxidase (MPO) and paraoxonase 1 (PON1) are high-density lipoprotein-associated (HDL-associated) proteins mechanistically linked to inflammation, oxidant stress, and atherosclerosis. MPO is a source of ROS during inflammation and can oxidize apolipoprotein A1 (APOA1) of HDL, impairing its atheroprotective functions. In contrast, PON1 fosters systemic antioxidant effects and promotes some...

Journal: :Journal of lipid research 2008
Xenia Moren Sara Deakin Ming-Lin Liu Marja-Riitta Taskinen Richard W James

The subfraction distribution of HDL-associated peptides has implications for their functions and the impact of pathological modifications to lipoprotein metabolism on these functions. We have analyzed the subfraction distribution of paraoxonase-1 (PON1) and the consequences for enzyme activity and stability. HDL subfractions were defined by the presence (LpA-I,A-II) or absence (LpA-I) of apolip...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2003
Gail P Jarvik Thomas S Hatsukami Chris Carlson Rebecca J Richter Rachel Jampsa Victoria H Brophy Sadie Margolin Mark Rieder Deborah Nickerson Gerard D Schellenberg Patrick J Heagerty Clement E Furlong

OBJECTIVE The effects of paraoxonase (PON1) activity and of genetic variation in the PON1 promoter and coding region on carotid artery disease (CAAD) were investigated. METHODS AND RESULTS We identified functional promoter polymorphisms and examined their effects in a cohort with and without CAAD. We used the full sequences in 23 white subjects to determine the linkage disequilibrium (LD) str...

Journal: :Clinical chemistry 2002
Natàlia Ferré Jordi Camps Eduard Prats Elisabet Vilella Antoni Paul Lídia Figuera Jorge Joven

BACKGROUND Paraoxonase 1 (PON1) is an ester hydrolase present in serum and in the liver. The aims of the present study were to investigate the following: (a) the relationship between serum PON1 activity alterations and the degree of liver damage in patients with chronic liver disease; (b) the influence of genetic variability on serum PON1 activity; and (c) the efficacy of serum PON1 activity me...

Journal: :JAMA 2008
Tamali Bhattacharyya Stephen J Nicholls Eric J Topol Renliang Zhang Xia Yang David Schmitt Xiaoming Fu Mingyuan Shao Danielle M Brennan Stephen G Ellis Marie-Luise Brennan Hooman Allayee Aldons J Lusis Stanley L Hazen

CONTEXT Paraoxonase 1 (PON1) is reported to have antioxidant and cardioprotective properties. The relationship between PON1 genotypes and functional activity with systemic measures of oxidative stress and cardiovascular disease (CVD) risk in humans has not been systematically investigated. OBJECTIVE To investigate the relationship of genetic and biochemical determinants of PON1 activity with ...

Journal: :Folia neuropathologica 2013
Małgorzata Ewa Bednarska-Makaruk Tomasz Krzywkowski Alla Graban Wanda Lipczyńska-Łojkowska Anna Bochyńska Maria Rodo Hanna Wehr Danuta Krystyna Ryglewicz

Paraoxonase 1 (PON1) activity was determined using phenylacetate as substrate (arylesterase activity) in 304 individuals with dementia--136 recognised as probable Alzheimer's disease (AD), 64 as dementia of vascular origin (VaD) and 104 as mixed dementia (MD) and in 129 persons without symptoms of dementia and in a good general health. -108C>T polymorphism in the PON1 gene promoter and p.Q192R ...

2008
Tiffany L Graves John E Scott

PON1 has been demonstrated to be the serum enzyme responsible for detoxifying organophosphate chemical weapons and plays a protective role against atherosclerosis. In order to identify small molecules that modulate PON1 activity in serum, we developed a high throughput kinetic absorbance assay using mouse serum and the organophosphate paraoxon. The IC(50) value obtained for the known PON1 inhib...

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