A monospecific antibody against calf thymus DNA ligase composed of a single polypeptide with Mr = 130,000 cross-reacts with rodent and calf thymus DNA ligases. The antibody precipitates a single Mr = 200,000 polypeptide from detergent lysates of [3H] leucine-labeled mouse Ehrlich tumor cells and calf thymocytes. Pulse-chase experiments show that the Mr = 200,000 polypeptide in Ehrlich tumor cel...

Tirzepatide, a glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 agonist has recently been approved by FDA for type 2 diabetes in adults as single dose weekly. Tirzepatide is phase 3 development with obesity or overweight weight-related comorbidity. also under evaluation treatment of non-alcoholic steatohepatitis, heart faialure obstructive sleep apnea.

Tissue polypeptide antigen, measured by both a polyclonal antibody (TPA IRMA Prolifigen) and a monoclonal antibody prototype kit (TPA-M IRMA Prolifigen), and the tissue polypeptide specific antigen were evaluated. The markers were measured in 266 serum samples and in 291 tumour cytosols from patients with primary breast cancer. The three markers were available in matched pairs of both serum and...